ChemicalBook > CAS DataBase List > ethyl 1-acetylcyclopropanecarboxylate

ethyl 1-acetylcyclopropanecarboxylate

Product Name
ethyl 1-acetylcyclopropanecarboxylate
CAS No.
32933-03-2
Chemical Name
ethyl 1-acetylcyclopropanecarboxylate
Synonyms
thyl 1-acetylcyclopropanecarboxylate;Ethyl 1-acetylcyclopropan-carboxylate;ethyl 1-acetylcyclopropanecarboxylate;Ethyl 1-acetylcyclopropane-1-carboxylate;1-Acetylcyclopropancarbonsaeure-ethylester;1-Acetyl-cyclopropanecarboxylic acid ethyl ester;1-acetyl-1-cyclopropanecarboxylic acid ethyl ester;Cyclopropanecarboxylic acid, 1-acetyl-, ethyl ester;1-acetyl-Cyclopropanecarboxylic acid ethyl ester (8CI 9CI ACI);Cyclopropanecarboxylic acid, 1-acetyl-, ethyl ester (8CI, 9CI, ACI)
CBNumber
CB22499747
Molecular Formula
C8H12O3
Formula Weight
156.18
MOL File
32933-03-2.mol
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ethyl 1-acetylcyclopropanecarboxylate Property

Boiling point:
42-44 °C(Press: 2 Torr)
Density 
1.139±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C8H12O3/c1-3-11-7(10)8(4-5-8)6(2)9/h3-5H2,1-2H3
InChIKey
DISZFIFAESWGBI-UHFFFAOYSA-N
SMILES
C1(C(C)=O)(C(OCC)=O)CC1
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Safety

HS Code 
2902190000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PH018197
Product name
(3-Oxocyclohexyl)acetic acid
Purity
AldrichCPR
Packaging
1G
Price
$201
Updated
2023/06/20
TCI Chemical
Product number
E1442
Product name
Ethyl 1-Acetylcyclopropane-1-carboxylate
Purity
min. 98.0 %
Packaging
1G
Price
$94
Updated
2025/07/31
TCI Chemical
Product number
E1442
Product name
Ethyl 1-Acetylcyclopropane-1-carboxylate
Purity
min. 98.0 %
Packaging
5G
Price
$284
Updated
2025/07/31
TRC
Product number
E896430
Product name
Ethyl1-acetylcyclopropanecarboxylate
Packaging
100mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
077028
Product name
Ethyl 1-acetylcyclopropane-1-carboxylate
Purity
>95%
Packaging
500mg
Price
$74
Updated
2021/12/16
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ethyl 1-acetylcyclopropanecarboxylate Chemical Properties,Usage,Production

Uses

ethyl 1-methyl cyclopropanecarboxylate is an important pharmaceutical intermediate used in the addition of cyclopropane.

Synthesis

141-97-9

106-93-4

32933-03-2

Step 1) Synthesis of ethyl 1-acetylcyclopropanecarboxylate: To a solution of ethyl 3-oxobutanoate (26 g, 200 mmol) in acetone (500 mL) was added potassium carbonate (82.8 g, 600 mmol) followed by 1,2-dibromoethane (45.12 g, 240 mmol). The reaction mixture was refluxed for 24 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography with an eluent ratio of 1:50 (v/v) ethyl acetate/hexane to afford the target compound ethyl 1-acetylcyclopropanecarboxylate as a colorless oil (18.7 g, 60% yield). Mass spectrum (ESI, cation mode) m/z: 157 (M+1); 1H NMR (400 MHz, CDCl3) δ: 1.25-1.29 (t, J=7.2 Hz, 3H), 1.45 (s, 4H), 2.45 (s, 3H), 4.18-4.20 (q, 2H).

References

[1] Tetrahedron Letters, 2005, vol. 46, # 4, p. 635 - 638
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004, vol. 43, # 2, p. 420 - 422
[3] Tetrahedron Asymmetry, 2010, vol. 21, # 5, p. 631 - 635
[4] Journal of Organic Chemistry, 2011, vol. 76, # 8, p. 2807 - 2813
[5] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983, vol. 19, # 6, p. 644 - 650

ethyl 1-acetylcyclopropanecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ethyl 1-acetylcyclopropanecarboxylate manufacturers

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
ethyl 1-acetylcyclopropanecarboxylate 32933-03-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2 MTs
Release date
2024-08-06
Shaanxi Dideu Medichem Co. Ltd
Product
ethyl 1-acetylcyclopropanecarboxylate 32933-03-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-13
Career Henan Chemical Co
Product
ethyl 1-acetylcyclopropanecarboxylate 32933-03-2
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

32933-03-2, ethyl 1-acetylcyclopropanecarboxylateRelated Search:


  • ethyl 1-acetylcyclopropanecarboxylate
  • 1-Acetyl-cyclopropanecarboxylic acid ethyl ester
  • Ethyl 1-acetylcyclopropane-1-carboxylate
  • thyl 1-acetylcyclopropanecarboxylate
  • 1-acetyl-1-cyclopropanecarboxylic acid ethyl ester
  • Cyclopropanecarboxylic acid, 1-acetyl-, ethyl ester
  • Cyclopropanecarboxylic acid, 1-acetyl-, ethyl ester (8CI, 9CI, ACI)
  • 1-acetyl-Cyclopropanecarboxylic acid ethyl ester (8CI 9CI ACI)
  • 1-Acetylcyclopropancarbonsaeure-ethylester
  • Ethyl 1-acetylcyclopropan-carboxylate
  • 32933-03-2