ChemicalBook > CAS DataBase List > 2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester

2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester

Product Name
2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester
CAS No.
944401-67-6
Chemical Name
2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester
Synonyms
6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine;2-Amino-6-fluoro pyridine-5-boronic acid picol ester;2-Fluoro-6-aminopyridine-3-boronic acid pinacol ester;6-Amino-2-fluoropyridine-3-boronic acid pinacol ester;2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester;2-Pyridinamine, 6-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;6-Fluoro-5-(4，4，5，5-tetramethyl-1，3，2-dioxaborolan-2-yl)pyridin-2-amine??6-;6-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2-imine
CBNumber
CB22499848
Molecular Formula
C11H16BFN2O2
Formula Weight
238.07
MOL File
944401-67-6.mol
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2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester Property

Density 
1.15
storage temp. 
2-8°C(protect from light)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0061090
Product name
6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
Packaging
250mg
Price
$199
Updated
2021/12/16
Matrix Scientific
Product number
098668
Product name
6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
Purity
95+%
Packaging
250mg
Price
$246
Updated
2021/12/16
ChemScene
Product number
CS-0061090
Product name
6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
Packaging
100mg
Price
$119
Updated
2021/12/16
AK Scientific
Product number
6147AC
Product name
6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
Packaging
250mg
Price
$327.2
Updated
2021/12/16
ChemScene
Product number
CS-0061090
Product name
6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
Packaging
1g
Price
$418
Updated
2021/12/16
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2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester Chemical Properties,Usage,Production

Synthesis

944401-65-4

73183-34-3

944401-67-6

To a dry 50 mL three-necked flask was added 2-amino-5-bromo-6-fluoropyridine (370 mg, 1.93 mmol), potassium acetate (569 mg, 5.8 mmol), pinacol ester of bis(boronic acid) (538 mg, 2.12 mmol) and dioxane (15 mL). After bubbling through argon for 15 minutes, 1,1'-bis(diphenylphosphino)ferrocene palladium(II) chloride dichloromethane adduct (79 mg, 0.09 mmol) was added. The reaction mixture was refluxed in an oil bath at 115 °C for 4 h under argon protection. After completion of the reaction, the solvent was removed by distillation under reduced pressure and ethyl acetate (150 mL) was added to dissolve the residue. The organic phase was washed sequentially with water (3 x 40 mL) and saturated sodium chloride solution (300 mL), dried over anhydrous sodium sulfate, filtered and concentrated. Purification by silica gel column chromatography (eluent: 30% ethyl acetate/hexane) afforded the target product 2-fluoro-6-amino-5-pyridineboronic acid ester (161 mg, 35% yield).LC-MS (m/z): 157 ([M+H]+ of boronic acid from in situ hydrolysis product in liquid chromatography).1H NMR (CDCl3): δ 7.86 (t, J = 8.4 Hz, 1H), 6.29 (dd, J = 8.1, 2.7 Hz, 1H), 4.70 (br s, 2H), 1.32 (s, 12H).

References

[1] Patent: WO2007/84786, 2007, A1. Location in patent: Page/Page column 101-102
[2] Patent: WO2012/109423, 2012, A1. Location in patent: Page/Page column 24

2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester 944401-67-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Amino-6-fluoro pyridine-5-boronic acid pinacol ester 944401-67-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

944401-67-6, 2-Amino-6-fluoro pyridine-5-boronic acid pinacol esterRelated Search:


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  • 944401-67-6