2,5-Dibromophenylacetic acid
- Product Name
- 2,5-Dibromophenylacetic acid
- CAS No.
- 203314-28-7
- Chemical Name
- 2,5-Dibromophenylacetic acid
- Synonyms
- Dibromophenylacetic acid;5-Dibromophenylacetic acid;2,5-Dibromophenylacetic acid;2,5-Dibromobenzeneacetic acid;Benzeneacetic acid, 2,5-dibromo-;2-(2,5-DibroMophenyl)acetic acid
- CBNumber
- CB22503585
- Molecular Formula
- C8H6Br2O2
- Formula Weight
- 293.94
- MOL File
- 203314-28-7.mol
2,5-Dibromophenylacetic acid Property
- Boiling point:
- 376.4±27.0 °C(Predicted)
- Density
- 1.969±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- claggy powder
- pka
- 3.87±0.10(Predicted)
- color
- Cream to faint tan
- InChI
- InChI=1S/C8H6Br2O2/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3H,4H2,(H,11,12)
- InChIKey
- NKZKFWYEXDBOTP-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC(Br)=CC=C1Br
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- D425705
- Product name
- 2-(2,5-Dibromophenyl)aceticAcid
- Packaging
- 10g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- CS-M3358
- Product name
- (2,5-Dibromophenyl)aceticacid
- Purity
- 99.95%
- Packaging
- 25g
- Price
- $212
- Updated
- 2021/12/16
- Product number
- 2621-9-13
- Product name
- 2,5-Dibromophenylacetic acid
- Packaging
- 5G
- Price
- $149
- Updated
- 2021/12/16
- Product number
- FD32839
- Product name
- 2-(2,5-Dibromophenyl)acetic acid
- Packaging
- 5G
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 066946
- Product name
- 2,5-Dibromophenylacetic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $74
- Updated
- 2021/12/16
2,5-Dibromophenylacetic acid Chemical Properties,Usage,Production
Uses
2-(2,5-Dibromophenyl)acetic Acid is used as a reactant in the synthesis of MK-8742, a HCV NS5a inhibitor.
Synthesis
74533-21-4
203314-28-7
In a 500 mL four-necked reaction flask, 82 g of 2-(2,5-dibromophenyl)acetonitrile was added to 400 mL of aqueous 2 N sodium hydroxide, and the mixture was heated to 100 °C and refluxed. The reaction progress was monitored by TLC. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with 36% hydrochloric acid by slow dropwise addition to 8. The aqueous layer was separated by extraction with ethyl acetate. Subsequently, the pH of the aqueous layer was adjusted to 1-2 with 36% hydrochloric acid, at which point a solid precipitated. The off-white solid 2-(2,5-dibromophenyl)acetic acid was collected by filtration and dried to give 73 g in 83% yield.
References
[1] Patent: CN107759459, 2018, A. Location in patent: Paragraph 0007; 0008; 0017; 0018
[2] Synlett, 2011, # 17, p. 2525 - 2528
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3563 - 3580
2,5-Dibromophenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,5-Dibromophenylacetic acid Suppliers
- Tel
- 0535-7295056 15692356085
- sdycc1234@163.com
- Country
- China
- ProdList
- 158
- Advantage
- 58
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-31038972,31038973 17321035817
- Fax
- +86-21-51385350
- sales@harvest-chem.com
- Country
- China
- ProdList
- 2816
- Advantage
- 64
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- 022-58013646 13011382049
- Fax
- 022-23854368
- sales@jinyudachem.com
- Country
- China
- ProdList
- 1930
- Advantage
- 55
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
View Lastest Price from 2,5-Dibromophenylacetic acid manufacturers
- Product
- 2,5-Dibromophenylacetic acid 203314-28-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24