(2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
- Product Name
- (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
- CAS No.
- 1103738-26-6
- Chemical Name
- (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
- Synonyms
- SOTA-014;Dapagliflozin-24;Dapagliflozin Impurity 43;5-Iodo-2-chIoro-4’-ethoxydiphenyImethanone;5-Iodo-2-chloro-4’-ethoxydiphenylmethanone;5-lodo-2-chloro-4z-ethoxydiphenylmethanone;5-Iodo-2-ChIorophenyI 4-EthoxyphenyI Methanone;(2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone;(5-Iodo-2-chlorophenyl)(4-ethoxyphenyl)methanone;Methanone,(2-chloro-5-iodophenyl)(4-ethoxyphenyl)-
- CBNumber
- CB22504719
- Molecular Formula
- C15H12ClIO2
- Formula Weight
- 386.61
- MOL File
- 1103738-26-6.mol
(2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone Property
- Boiling point:
- 461.3±40.0 °C(Predicted)
- Density
- 1.597±0.06 g/cm3(Predicted)
- vapor pressure
- 0.0±1.1 mmHg at 25°C
- Flash point:
- 232.8±27.3 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C15H12ClIO2/c1-2-19-12-6-3-10(4-7-12)15(18)13-9-11(17)5-8-14(13)16/h3-9H,2H2,1H3
- InChIKey
- BGRJXWMKCUZBIG-UHFFFAOYSA-N
- SMILES
- C(C1=CC(I)=CC=C1Cl)(C1=CC=C(OCC)C=C1)=O
N-Bromosuccinimide Price
- Product number
- 5263DN
- Product name
- (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- CD12180680
- Product name
- (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
- Purity
- 97%
- Packaging
- 5g
- Price
- $446
- Updated
- 2021/12/16
- Product number
- 1103738266
- Product name
- (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
- Packaging
- 5g
- Price
- $454.5
- Updated
- 2021/12/16
- Product number
- A188398
- Product name
- (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
- Purity
- 97%
- Packaging
- 100mg
- Price
- $18
- Updated
- 2021/12/16
- Product number
- A188398
- Product name
- (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
- Purity
- 97%
- Packaging
- 250mg
- Price
- $25
- Updated
- 2021/12/16
(2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone Chemical Properties,Usage,Production
Uses
(2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone is a pharmaceutical intermediate in pharmaceutical synthesis and scientific research. It is an impurity of dapagliflozin, which is a medication for adults with chronic kidney disease (CKD), heart failure with symptoms, and type 2 diabetes. (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone is applicable to drug development, production and declaration.
Synthesis
281652-58-2
103-73-1
1103738-26-6
A 2L three-necked round-bottomed flask with a mechanical stirrer (equipped with a jacket, a rubber septum with a temperature probe, and a pressure-equalizing charging funnel with a gas bubbler) was filled with aluminum chloride (97.68 g, 0.733 mol, 1.04 eq.) and methylene chloride (0.65 L, KF). The suspension was stirred under nitrogen protection and cooled to about 6 °C. Subsequently, phenethyl ether (90 mL, 0.712 mol, 1.01 eq.) was added slowly over 7 minutes, keeping the internal temperature of the reaction below 9 °C. The amount of water in the reaction mixture was 0.003 wt%. The resulting orange solution was diluted with dichloromethane (75 mL) and cooled to -7 °C. Next, a solution of 2-chloro-5-iodobenzoyl chloride (<0.706 mol) in 350 mL of dichloromethane was added dropwise over 13 min, controlling the internal temperature to not exceed the set point. The reaction mixture was warmed slightly and maintained at +5 °C for 2 h. After HPLC analysis confirmed the completion of the reaction, the reaction mixture was quenched by slowly pouring it into 450 mL of pre-cooled (5 °C) aqueous 2N HCl solution. The quenching process was completed in batches over 10 min, ensuring that the internal temperature did not exceed 28°C. The quenched two-phase mixture was stirred at 20 °C for 45 min, and the lower organic phase was separated and washed sequentially with aqueous 1N HCl, saturated aqueous sodium bicarbonate (200 mL each time) and saturated aqueous sodium chloride (200 mL). The washed organic phase was concentrated on a rotary evaporator to give the crude product (2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone as an off-white solid (268.93 g, HPLC purity 99.0 area %, 220 nm; regional isomer content 1.0 area %, 200 nm; yield 98.5%).
References
[1] Patent: US2009/30198, 2009, A1. Location in patent: Page/Page column 8-9
[2] Patent: CN106316803, 2017, A. Location in patent: Paragraph 0017
[3] Patent: US2010/16422, 2010, A1. Location in patent: Page/Page column 5
[4] Patent: EP2332947, 2011, A1. Location in patent: Page/Page column 7-8
[5] Patent: EP2661256, 2018, B1. Location in patent: Paragraph 0095
(2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone Preparation Products And Raw materials
Raw materials
Preparation Products
(2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone Suppliers
- Tel
- 0512-87815088 18015562287
- Fax
- 0512-69233866
- xmwang@xiaolitech.com
- Country
- China
- ProdList
- 66
- Advantage
- 58
- Tel
- 15189849794
- xiaojin.wu@hsdk-pharmatech.cn
- Country
- China
- ProdList
- 24
- Advantage
- 58
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 18939837085
- Fax
- 2880152141(QQ)
- youchemicals@gmail.com
- Country
- China
- ProdList
- 1839
- Advantage
- 55
- Tel
- 18680818008/15802381793
- Fax
- 086-23-86109835
- cqudgh@126.com
- Country
- China
- ProdList
- 57
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 021-50426030 13856289449
- Fax
- 021-50426030
- 2630597085@qq.com
- Country
- China
- ProdList
- 1889
- Advantage
- 55
- Tel
- 022-25349927 15900252761
- Fax
- 022-25349927
- saichen_sales@hotmail.com
- Country
- China
- ProdList
- 101
- Advantage
- 55
- Tel
- 021-58088081 Q2635253576
- Fax
- QQ3382968513
- hailey@shsendpharm.com
- Country
- China
- ProdList
- 1984
- Advantage
- 55
- Tel
- 400-027-6116 18086000087
- Fax
- QQ: 2680733325
- sales@chemgreatwall.com
- Country
- China
- ProdList
- 1559
- Advantage
- 55
- Tel
- 021-58892003
- info@qiaochem.com
- Country
- China
- ProdList
- 6059
- Advantage
- 65
- Tel
- +86-010-60279497 +86-15646567669
- Fax
- 010-60279497
- sales01@cooperate-pharm.com
- Country
- China
- ProdList
- 137
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 0317-5296180 15533709196
- Fax
- 0317-5106596
- sale@enkepharma.com
- Country
- China
- ProdList
- 2267
- Advantage
- 55
- Tel
- 025-025-58367986 18913956109
- Fax
- QQ:3209878052
- amy.xiang@ally-chem.com
- Country
- China
- ProdList
- 568
- Advantage
- 58
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- Fax
- -
- 13006575422@163.com
- Country
- China
- ProdList
- 6355
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-20432229
- Fax
- QQ2412110556
- 2412110556@qq.com
- Country
- China
- ProdList
- 6017
- Advantage
- 55
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 021-54285032 18116461626
- Fax
- 021-54285032
- 25493162@qq.com
- Country
- China
- ProdList
- 148
- Advantage
- 58
- Tel
- 0371-55051623 18137891487
- Fax
- QQ：2853979817
- 2853979817@qq.com
- Country
- China
- ProdList
- 9981
- Advantage
- 58
- Tel
- 0371-037163312495,13303845143 13303845143
- Fax
- QQ3001379618
- 3001379618@qq.com
- Country
- China
- ProdList
- 10267
- Advantage
- 58
- Tel
- 025-84767922 18936879710
- sales@abydoscientific.com
- Country
- China
- ProdList
- 1002
- Advantage
- 58
- Tel
- 021-18017654 18017654809
- Fax
- 2271705492
- sales@vigorchem.cn
- Country
- China
- ProdList
- 958
- Advantage
- 58
- Tel
- +86-188369842 +86-15618151133
- Fax
- QQ188369842
- 188369842@qq.com
- Country
- China
- ProdList
- 1959
- Advantage
- 58
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23541
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +8617013299288
- dj@sgtlifesciences.com
- Country
- China
- ProdList
- 12373
- Advantage
- 58
- Tel
- 571-86758373 +8613588754946
- Fax
- 0086-571-81131109
- sales@huarongpharm.com
- Country
- CHINA
- ProdList
- 3148
- Advantage
- 58
- Tel
- +8615604608665 15604608665
- dominicguo@gk-bio.com
- Country
- CHINA
- ProdList
- 9414
- Advantage
- 58
- Tel
- 020-36607679 19925672674
- Fax
- QQ 3008233717
- 3008233746@qq.com
- Country
- China
- ProdList
- 9883
- Advantage
- 12
- Tel
- 15189846850 13815846020
- 710163098@qq.com
- Country
- China
- ProdList
- 909
- Advantage
- 58
- Tel
- 15921040873
- 1434142450@qq.com
- Country
- CHINA
- ProdList
- 7649
- Advantage
- 58
- Tel
- +86-0519-88299272
- info@edengenechem.com
- Country
- China
- ProdList
- 2176
- Advantage
- 58
- Tel
- 2710913286@.com
- 1513643261@qq.com
- Country
- China
- ProdList
- 14246
- Advantage
- 58
- Tel
- 021-021-13773155751 19975051755
- 260924549@qq.com
- Country
- China
- ProdList
- 10524
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- 021-58123769 17721400256
- info@paynepharm.com
- Country
- China
- ProdList
- 1285
- Advantage
- 58
- Tel
- 021-58123769 18678586262
- info@paynepharm.com
- Country
- China
- ProdList
- 1354
- Advantage
- 58
- Tel
- 0755-61348847 17820674378
- Fax
- 0755-21016893
- 2682116078@qq.com
- Country
- China
- ProdList
- 7843
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 15210893940; 15116916250
- Fax
- QQ: 237008221
- chemistryliu@163.com
- Country
- China
- ProdList
- 7327
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
- Tel
- 400-820-6829
- sales@mitachieve.com
- Country
- China
- ProdList
- 8860
- Advantage
- 58
- Tel
- 0755-0755-83725350 13380397412
- Fax
- 0755-28094224
- 3001280422@qq.com
- Country
- China
- ProdList
- 10001
- Advantage
- 58
- Tel
- 15871722230
- Fax
- 2796190295
- 15871722230@163.com
- Country
- China
- ProdList
- 4686
- Advantage
- 58
View Lastest Price from (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone manufacturers
- Product
- Dapagliflozin Impurity 12 1103738-26-6
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-05-16
- Product
- Dapagliflozin Impurity 12 1103738-26-6
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 5g
- Release date
- 2025-02-07
- Product
- Dapagliflozin Impurity 43
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 5g
- Release date
- 2025-02-11