ChemicalBook > CAS DataBase List > 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride

2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride

Product Name
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
CAS No.
324523-20-8
Chemical Name
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
Synonyms
NPS-2143 HCL;NPS-2143 (Mono HCl);NPS2143;NPS 2143 HCL;SB-262470-A hydrochloride;NPS2143 hydrochloride, >=98%;NPS-2143/SB-262470A hydrochloride);NPS-2143 hydrochloride (SB-262470A);NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist;2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride;(R)-2-Chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile hydrochloride
CBNumber
CB22509916
Molecular Formula
C24H26Cl2N2O2
Formula Weight
445.38
MOL File
324523-20-8.mol
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2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride Property

storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
form 
powder
color 
white to beige
optical activity
[α]20/D +20 to +24°, c = 1.0 in methanol
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Safety

Hazard Codes 
Xn,N
Risk Statements 
20/21/22-50/53
Safety Statements 
36/37-60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0362
Product name
NPS2143 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$158
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0362
Product name
NPS2143 hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$631
Updated
2024/03/01
Cayman Chemical
Product number
17903
Product name
NPS 2143 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
17903
Product name
NPS 2143 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
17903
Product name
NPS 2143 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$163
Updated
2024/03/01
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2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride Chemical Properties,Usage,Production

Description

Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. NPS 2143 is a potent and selective antagonist of CaSR (IC50 = 43 nM) that stimulates PTH secretion from parathyroid cells in vitro (EC50 = 39 nM). It is effective in vivo, causing a sustained increase in plasma PTH in rats when given intravenously. Daily oral administration of NPS 2143 to osteopenic ovariectomized rats results in a dramatic increase in bone turnover, as well as increased circulating PTH levels.

Uses

NPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis.

Biochem/physiol Actions

NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.

storage

Desiccate at RT

2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride Suppliers

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324523-20-8, 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochlorideRelated Search:

N,N-DIETHYLBENZAMIDE Permethrin

  • 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
  • NPS-2143 HCL
  • NPS-2143 (Mono HCl)
  • 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1)
  • NPS2143;NPS 2143 HCL
  • SB-262470-A hydrochloride
  • NPS2143 hydrochloride, >=98%
  • NPS-2143 hydrochloride (SB-262470A)
  • (R)-2-Chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile hydrochloride
  • NPS2143,NPS-2143,CaSR,NPS 2143 hydrochloride,Calcium-sensing receptor,inhibit,SB-262470A,Inhibitor,NPS 2143,NPS2143 hydrochloride
  • NPS-2143/SB-262470A hydrochloride)
  • NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist
  • 324523-20-8
  • C24H25ClN2O2HCl