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Acotiamide Hydrochloride

Product Name
Acotiamide Hydrochloride
CAS No.
185104-11-4
Chemical Name
Acotiamide Hydrochloride
Synonyms
Acotiamide-d6 HCl;Acotiamide hydrochloride;Acotiamide Impurity 14 HCl;Acotiamide dihydrochloride;Acotiamide Impurity 20 HCl;Acetylformamide hydrochloride;Acotiamide (hydrochloride) (Acotiamide Impurity);N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoy;N-[2-[Bisisopropylamino]-ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide HCl;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride
CBNumber
CB22510118
Molecular Formula
C21H31ClN4O5S
Formula Weight
487.01
MOL File
185104-11-4.mol
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Acotiamide Hydrochloride Property

storage temp. 
Sealed in dry,Store in freezer, under -20°C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A190260
Product name
AcotiamideHydrochloride
Packaging
5mg
Price
$160
Updated
2021/12/16
AK Scientific
Product number
0101AP
Product name
Acotiamidehydrochloride
Packaging
250mg
Price
$212
Updated
2021/12/16
Chemenu
Product number
CM133484
Product name
N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamidehydrochloride
Purity
97%
Packaging
1g
Price
$281
Updated
2021/12/16
Crysdot
Product number
CD11178508
Product name
Acotiamidehydrochloride
Purity
97%
Packaging
1g
Price
$297
Updated
2021/12/16
Ambeed
Product number
A111223
Product name
Acotiamidehydrochloride
Purity
98%
Packaging
5g
Price
$417
Updated
2021/12/16
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Acotiamide Hydrochloride Chemical Properties,Usage,Production

Description

Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

Uses

Acotiamide Hydrochloride is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats (1,2). Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.

Biological Activity

Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.

Acotiamide Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Acotiamide Hydrochloride Suppliers

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View Lastest Price from Acotiamide Hydrochloride manufacturers

Anhui Dexinjia Biopharm Co., Ltd
Product
Acotiamide hydrochloride 185104-11-4
Price
US $200.00-199.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20 TONS
Release date
2024-05-17
Wuhan Xinhao Biotechnology Co., Ltd
Product
Acotiamide hydrochloride 185104-11-4
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2024-03-11
PNP Biotech Co. Ltd
Product
Acotiamide hydrochloride 185104-11-4
Price
US $0.00/kg
Min. Order
25kg
Purity
≥99%
Supply Ability
Inquiry
Release date
2022-10-28

185104-11-4, Acotiamide HydrochlorideRelated Search:


  • Acotiamide hydrochloride
  • N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride
  • N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide,hydrochloride
  • Acotiamide-d6 HCl
  • N-[2-[Bisisopropylamino]-ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide HCl
  • N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoy
  • Acetylformamide hydrochloride
  • Acotiamide dihydrochloride
  • 4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, hydrochloride (1:1)
  • Acotiamide Impurity 14 HCl
  • Acotiamide (hydrochloride) (Acotiamide Impurity)
  • Acotiamide Impurity 20 HCl
  • 185104-11-4
  • C21H30N4O5SHCl