ChemicalBook > CAS DataBase List > Acotiamide Hydrochloride
Acotiamide Hydrochloride
- Product Name
- Acotiamide Hydrochloride
- CAS No.
- 185104-11-4
- Chemical Name
- Acotiamide Hydrochloride
- Synonyms
- Acotiamide-d6 HCl;Acotiamide hydrochloride;Acotiamide Impurity 20 HCl;Acotiamide dihydrochloride;Acotiamide Impurity 14 HCl;Acetylformamide hydrochloride;Acotiamide (hydrochloride) (Acotiamide Impurity);N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoy;N-[2-[Bisisopropylamino]-ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide HCl;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride
- CBNumber
- CB22510118
- Molecular Formula
- C21H31ClN4O5S
- Formula Weight
- 487.01
- MOL File
- 185104-11-4.mol
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Acotiamide Hydrochloride Property
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- InChIKey
- VQEKQYLTAIVCBW-UHFFFAOYSA-N
- SMILES
- C(C1C(=CC(OC)=C(OC)C=1)O)(=O)NC1SC=C(C(=O)NCCN(C(C)C)C(C)C)N=1.Cl
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N-Bromosuccinimide Price
TRC
- Product number
- A190260
- Product name
- AcotiamideHydrochloride
- Packaging
- 5mg
- Price
- $160
- Updated
- 2021/12/16
AK Scientific
- Product number
- 0101AP
- Product name
- Acotiamidehydrochloride
- Packaging
- 250mg
- Price
- $212
- Updated
- 2021/12/16
Chemenu
- Product number
- CM133484
- Product name
- N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamidehydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $281
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11178508
- Product name
- Acotiamidehydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $297
- Updated
- 2021/12/16
Ambeed
- Product number
- A111223
- Product name
- Acotiamidehydrochloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $417
- Updated
- 2021/12/16
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Acotiamide Hydrochloride Chemical Properties,Usage,Production
Description
Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.
Uses
Acotiamide Hydrochloride is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats (1,2). Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.
Biological Activity
Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
Acotiamide Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Acotiamide Hydrochloride manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide,hydrochloride 185104-11-4
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-23
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- Acotiamide hydrochloride 185104-11-4
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20
Anhui Dexinjia Biopharm Co., Ltd
- Product
- Acotiamide hydrochloride 185104-11-4
- Price
- US $200.00-199.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20 TONS
- Release date
- 2024-05-17
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