3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

Product Name: 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine
CAS No.: 30169-25-6
Chemical Name: 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine
Synonyms: 6-Bis(3;5-dimethyl-1H-pyrazol-1-yl)-1;3,6-bis(2,4-dimethylpyrrol-1-yl)-1,2,4,5-tetrazine;bis(3,5-diMethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine;3,6-Bis(2,4-DiMethyl-1H-pyrrol-1-yl)-1,2,4,5-tetrazine;3,6-BIS(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-1,2,4,5-TETRAAZIN;3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine;3,6-di (3,5-dimethyl-1H-pyrazol-1-yl) -1,2,4,5-tetrazine;1,2,4,5-Tetrazine, 3,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-;3,6-bis (3,5-dimethyl-1h-pyrazole-1-yl) - 1,2,4,5-tetrazine
CBNumber: CB22510138
Molecular Formula: C12H14N8
Formula Weight: 270.29
MOL File: 30169-25-6.mol

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3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine Property

Melting point:: 216-218℃
Boiling point:: 533.7±60.0 °C(Predicted)
Density: 1.44
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: -4.09±0.31(Predicted)
color: Red
InChI: InChI=1S/C12H14N8/c1-7-5-9(3)19(17-7)11-13-15-12(16-14-11)20-10(4)6-8(2)18-20/h5-6H,1-4H3
InChIKey: FPKOARNUITZHCF-UHFFFAOYSA-N
SMILES: N1C(N2C(C)=CC(C)=N2)=NN=C(N2C(C)=CC(C)=N2)N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: B429770
Product name: 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine
Packaging: 1g
Price: $140
Updated: 2021/12/16

Matrix Scientific

Product number: 096455
Product name: 3,6-Bis(2,4-Dimethyl-1H-pyrrol-1-yl)-1,2,4,5-tetrazine
Purity: 95+%
Packaging: 5g
Price: $245
Updated: 2021/12/16

AK Scientific

Product number: X5690
Product name: 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine
Packaging: 10g
Price: $428
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0388881
Product name: 3,6-BIS(2,4-DIMETHYL-1H-PYRROL-1-YL)-1,2,4,5-TETRAZINE
Purity: 95.00%
Packaging: 5MG
Price: $498.6
Updated: 2021/12/16

Matrix Scientific

Product number: 096455
Product name: 3,6-Bis(2,4-Dimethyl-1H-pyrrol-1-yl)-1,2,4,5-tetrazine
Purity: 95+%
Packaging: 25g
Price: $685
Updated: 2021/12/16

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3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine Chemical Properties,Usage,Production

Uses

3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine is a reagent used to prepare 3-arylamino-6-benzylamino-1,2,4,5-tetrazines with antimalarial activities.

Synthesis

30169-21-2

30169-25-6

General procedure for the synthesis of 3,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2-dihydro-1,2,4,5-tetrazine from 3,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine: 26.2 g of sodium nitrite was dissolved in 588 mL of water, 60 mL of dichloromethane was added, and the mixed solution was cooled to 0 °C. Subsequently, 37 g (0.136 mol) of 3,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2-dihydro-1,2,4,5-tetrazine was added to the solution and 18.67 mL (0.326 mol) of acetic acid was added slowly and dropwise. After the gas escape ceased, extraction was carried out with dichloromethane and the organic phase was washed with potassium carbonate solution. After drying over magnesium sulfate, the organic solvent was removed by rotary evaporation and finally recrystallized with ether to afford the target product 3,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine (33.45 g, 91% yield).

References

[1] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 8, p. 2049 - 2050
[2] Chemical Communications, 2013, vol. 49, # 87, p. 10275 - 10277
[3] Dalton Transactions, 2017, vol. 46, # 8, p. 2471 - 2478
[4] Journal of Chemical Crystallography, 2012, vol. 42, # 6, p. 600 - 605
[5] European Journal of Organic Chemistry, 2009, # 35, p. 6121 - 6128

3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine Suppliers

China 77 Finland 1 France 1 Germany 1 India 1 United States 6 Global 87

Henan Weituxi Chemical Technology Co., Ltd.

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Heze Bona Medical Technology Co., LTD

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Energy Chemical

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Bide Pharmatech Ltd.

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Finetech Industry Limited

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Shanghai Macklin Biochemical Co.,Ltd.

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View Lastest Price from 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine 30169-25-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-18

Career Henan Chemical Co

Product: 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine 30169-25-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100 kg
Release date: 2020-01-10

30169-25-6, 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazineRelated Search:

3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

3,6-Bis(2,4-DiMethyl-1H-pyrrol-1-yl)-1,2,4,5-tetrazine

3,6-BIS(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-1,2,4,5-TETRAAZIN

bis(3,5-diMethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

3,6-bis(2,4-dimethylpyrrol-1-yl)-1,2,4,5-tetrazine

3,6-bis (3,5-dimethyl-1h-pyrazole-1-yl) - 1,2,4,5-tetrazine

1,2,4,5-Tetrazine, 3,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-

5-dimethyl-1H-pyrazol-1-yl)-1

6-Bis(3

3,6-di (3,5-dimethyl-1H-pyrazol-1-yl) -1,2,4,5-tetrazine

30169-25-6

C12H14N8