PF 750

Product Name: PF 750
CAS No.: 959151-50-9
Chemical Name: PF 750
Synonyms: PF 750;N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide;N-Phenyl-4-(quinolin-3-ylMethyl)piperidine-1-carboxaMide;1-PiperidinecarboxaMide, N-phenyl-4-(3-quinolinylMethyl)-
CBNumber: CB22511241
Molecular Formula: C22H23N3O
Formula Weight: 345.44
MOL File: 959151-50-9.mol

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PF 750 Property

Boiling point:: 582.7±32.0 °C(Predicted)
Density: 1.226
storage temp.: Store at RT
solubility: DMSO: >10mg/mL
pka: 14.15±0.70(Predicted)
form: A crystalline solid
color: white to off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010908
Product name: PF-750
Purity: >98%
Packaging: 1mg
Price: $18
Updated: 2024/03/01

Cayman Chemical

Product number: 10010908
Product name: PF-750
Purity: >98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 10010908
Product name: PF-750
Purity: >98%
Packaging: 10mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 10010908
Product name: PF-750
Purity: >98%
Packaging: 50mg
Price: $553
Updated: 2024/03/01

Tocris

Product number: 3307
Product name: PF750
Purity: ≥98%(HPLC)
Packaging: 50
Price: $702
Updated: 2021/12/16

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PF 750 Chemical Properties,Usage,Production

Description

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC₅₀ values of 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM.

Uses

Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system

Definition

ChEBI: N-phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide is a member of quinolines.

Biochem/physiol Actions

PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM. PF-750 shows 10-fold better potency than URB597 (Sigma# U4133) after 30 min preincubation. PF-750 is highly selective on FAAH. Even at as high as 500 μM, it had no interactions with many tested enzymes, but URB597 and other known FAAH inhibitors did not perform well at low concentraction (100 μM).

PF 750 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 750 Suppliers

Canada 1 China 43 India 1 United Kingdom 1 United States 9 USA 1 Global 56

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4553
Advantage: 55

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: 1014988033@qq.com
Country: China
ProdList: 4969
Advantage: 55

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 56902
Advantage: 58

959151-50-9, PF 750Related Search:

PF 750

N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide

N-Phenyl-4-(quinolin-3-ylMethyl)piperidine-1-carboxaMide

1-PiperidinecarboxaMide, N-phenyl-4-(3-quinolinylMethyl)-

959151-50-9

Amines

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Heterocycles

Pfizer Compounds

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