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PF 750

Product Name
PF 750
CAS No.
959151-50-9
Chemical Name
PF 750
Synonyms
PF 750;N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide;N-Phenyl-4-(quinolin-3-ylMethyl)piperidine-1-carboxaMide;1-PiperidinecarboxaMide, N-phenyl-4-(3-quinolinylMethyl)-
CBNumber
CB22511241
Molecular Formula
C22H23N3O
Formula Weight
345.44
MOL File
959151-50-9.mol
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PF 750 Property

Boiling point:
582.7±32.0 °C(Predicted)
Density 
1.226
storage temp. 
Store at RT
solubility 
DMSO: >10mg/mL
pka
14.15±0.70(Predicted)
form 
A crystalline solid
color 
white to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10010908
Product name
PF-750
Purity
>98%
Packaging
1mg
Price
$18
Updated
2024/03/01
Cayman Chemical
Product number
10010908
Product name
PF-750
Purity
>98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
10010908
Product name
PF-750
Purity
>98%
Packaging
10mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
10010908
Product name
PF-750
Purity
>98%
Packaging
50mg
Price
$553
Updated
2024/03/01
Tocris
Product number
3307
Product name
PF750
Purity
≥98%(HPLC)
Packaging
50
Price
$702
Updated
2021/12/16
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PF 750 Chemical Properties,Usage,Production

Description

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values of 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM.

Uses

Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system

Definition

ChEBI: N-phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide is a member of quinolines.

Biochem/physiol Actions

PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM. PF-750 shows 10-fold better potency than URB597 (Sigma# U4133) after 30 min preincubation. PF-750 is highly selective on FAAH. Even at as high as 500 μM, it had no interactions with many tested enzymes, but URB597 and other known FAAH inhibitors did not perform well at low concentraction (100 μM).

PF 750 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 750 Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4601
Advantage
55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4983
Advantage
55
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58

959151-50-9, PF 750Related Search:


  • PF 750
  • N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide
  • N-Phenyl-4-(quinolin-3-ylMethyl)piperidine-1-carboxaMide
  • 1-PiperidinecarboxaMide, N-phenyl-4-(3-quinolinylMethyl)-
  • 959151-50-9
  • Amines
  • Aromatics
  • Heterocycles
  • Pfizer Compounds
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals