PF 750

Product Name: PF 750
CAS No.: 959151-50-9
Chemical Name: PF 750
Synonyms: PF 750;PF 750, 10 mM in DMSO;N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide;N-Phenyl-4-(quinolin-3-ylMethyl)piperidine-1-carboxaMide;1-PiperidinecarboxaMide, N-phenyl-4-(3-quinolinylMethyl)-
CBNumber: CB22511241
Molecular Formula: C22H23N3O
Formula Weight: 345.44
MOL File: 959151-50-9.mol

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PF 750 Property

Boiling point:: 582.7±32.0 °C(Predicted)
Density: 1.226
storage temp.: Store at RT
solubility: DMSO: >10mg/mL
pka: 14.15±0.70(Predicted)
form: A crystalline solid
color: white to off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010908
Product name: PF-750
Purity: >98%
Packaging: 1mg
Price: $18
Updated: 2024/03/01

Cayman Chemical

Product number: 10010908
Product name: PF-750
Purity: >98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 10010908
Product name: PF-750
Purity: >98%
Packaging: 10mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 10010908
Product name: PF-750
Purity: >98%
Packaging: 50mg
Price: $553
Updated: 2024/03/01

Tocris

Product number: 3307
Product name: PF750
Purity: ≥98%(HPLC)
Packaging: 50
Price: $702
Updated: 2021/12/16

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PF 750 Chemical Properties,Usage,Production

Description

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC₅₀ values of 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM.

Uses

Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system

Definition

ChEBI: N-phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide is a member of quinolines.

Biochem/physiol Actions

PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM. PF-750 shows 10-fold better potency than URB597 (Sigma# U4133) after 30 min preincubation. PF-750 is highly selective on FAAH. Even at as high as 500 μM, it had no interactions with many tested enzymes, but URB597 and other known FAAH inhibitors did not perform well at low concentraction (100 μM).

PF 750 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 750 Suppliers

Canada 1 China 46 India 1 United Kingdom 1 United States 9 USA 1 Global 59

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

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Country: United States
ProdList: 6251
Advantage: 58

Alfa Chemistry

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Country: United States
ProdList: 6814
Advantage: 0

Cayman Chemical Company

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Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Riedel-de Haen AG

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Santa Cruz Biotechnology, Inc.

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Email: scbt@scbt.com
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ProdList: 3597
Advantage: 60

959151-50-9, PF 750Related Search:

PF 750

N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide

N-Phenyl-4-(quinolin-3-ylMethyl)piperidine-1-carboxaMide

1-PiperidinecarboxaMide, N-phenyl-4-(3-quinolinylMethyl)-

PF 750, 10 mM in DMSO

959151-50-9

Amines

Aromatics

Heterocycles

Pfizer Compounds

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals