ChemicalBook > CAS DataBase List > 4-Chloroquinoline-6-carboxylic acid ethyl ester
4-Chloroquinoline-6-carboxylic acid ethyl ester
- Product Name
- 4-Chloroquinoline-6-carboxylic acid ethyl ester
- CAS No.
- 148018-34-2
- Chemical Name
- 4-Chloroquinoline-6-carboxylic acid ethyl ester
- Synonyms
- CAS:148018-34-2;Ethyl 4-chloro-6-quinolinecarboxylate;ethyl 4-chloroquinoline-6-carboxylate;4-Chloroquinoline-6-carboxylic acid ethyl ester;6-Quinolinecarboxylic acid, 4-chloro-, ethyl ester
- CBNumber
- CB22511504
- Molecular Formula
- C12H10ClNO2
- Formula Weight
- 235.67
- MOL File
- 148018-34-2.mol
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4-Chloroquinoline-6-carboxylic acid ethyl ester Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- HCH0368892
- Product name
- ETHYL-4-CHLOROQUINOLINE-6-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.44
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0368892
- Product name
- ETHYL-4-CHLOROQUINOLINE-6-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $982.8
- Updated
- 2021/12/16
Ambeed
- Product number
- A317681
- Product name
- Ethyl4-chloroquinoline-6-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
Ambeed
- Product number
- A317681
- Product name
- Ethyl4-chloroquinoline-6-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $206
- Updated
- 2021/12/16
Alichem
- Product number
- 148018342
- Product name
- Ethyl4-chloroquinoline-6-carboxylate
- Packaging
- 250mg
- Price
- $220.56
- Updated
- 2021/12/16
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4-Chloroquinoline-6-carboxylic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
127286-04-8
148018-34-2
The general procedure for the synthesis of ethyl 4-chloroquinoline-6-carboxylate from the compound (CAS:127286-04-8) was as follows: intermediate 41 (3 g, 13.8 mmol) was mixed with phosphorus trichloride (8 mL) and the reaction was stirred at 120 °C for 3 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation and subsequently quenched by adding crushed ice to the residue. Next, saturated aqueous sodium bicarbonate solution with ethyl acetate was added to the mixture to form a two-phase system. The organic and aqueous phases were separated and the aqueous phase was then extracted with ethyl acetate. All organic phases were combined, dried with anhydrous sodium sulfate, filtered to remove the desiccant, and the filtrate was evaporated under vacuum to remove the volatile components. Finally, the target product ethyl 4-chloroquinoline-6-carboxylate (2.19 g, 67% yield) was purified by silica gel column chromatography.
References
[1] Patent: US2008/234267, 2008, A1. Location in patent: Page/Page column 25
4-Chloroquinoline-6-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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