ChemicalBook > CAS DataBase List > MF-63

MF-63

Product Name: MF-63
CAS No.: 892549-43-8
Chemical Name: MF-63
Synonyms: MF-63;CS-2773;MF 63; MF-63;2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic;2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile;2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile;2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile;1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-
CBNumber: CB22512521
Molecular Formula: C23H11ClN4
Formula Weight: 378.81
MOL File: 892549-43-8.mol

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MF-63 Property

Boiling point:: 709.7±70.0 °C(Predicted)
Density: 1.49
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 11.34±0.30(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13217
Product name: MF63
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 13217
Product name: MF63
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 13217
Product name: MF63
Purity: ≥98%
Packaging: 10mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 13217
Product name: MF63
Purity: ≥98%
Packaging: 25mg
Price: $371
Updated: 2024/03/01

TRC

Product number: M340870
Product name: MF63
Packaging: 10mg
Price: $165
Updated: 2021/12/16

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MF-63 Chemical Properties,Usage,Production

Description

Microsomal prostaglandin E₂ synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE₂. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC₅₀ = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig mPGES-1 (IC₅₀ = 0.9 nM) but not mouse or rat mPGES-1. In guinea pigs or in mice expressing human mPGES-1, MF63 prevents LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain. It does not produce the gastrointestinal toxicity that is caused by non-selective COX inhibitors, although it markedly suppresses PGE₂ synthesis in the stomach.

Uses

MF 63 is a microsomal prostaglandin E2 synthase-1 (mPGES-1) the final enzyme in the synthesis of PGE2. Prevents LPS-induced hyperglasia. Anti-inflammatory, analgesic, anti-cancer agent.

in vitro

mf63 was found to be significantly more potent than those previously reported mpges-1 inhibitors with an intrinsic inhibitory potency on the recombinant human mpges-1 enzyme. furthermore, mf63 showed a pge2 whole cell inhibition in a549 cells and a human whole blood activity [1].

in vivo

in rodent species, mf63 inhibited guinea pig mpges-1 strongly but not the mouse or rat enzyme. when tested in the guinea pig and a knock-in (ki) mouse expressing human mpges-1, mf63 suppressed the synthesis of pge2 selectively, but not other prostaglandins that were inhibitable by nonsteroidal anti-inflammatory drugs (nsaid), yet remaided nsaid-like efficacy at inhibiting lipopolysaccharide-induced hyperalgesia, pyresis, and iodoacetate-induced osteoarthritic pain. additionally, mf63 did not cause nsaid-like gastrointestinal toxic effects, such as mucosal erosions or leakage in the ki mice or nonhuman primates, although mf63 markedly inhibited pge2 synthesis in the ki mouse stomach [1].

IC 50

0.9 and 1.3 nm for pig mpges-1 and human mpges-1

References

[1] xu d,rowland se,clark p,giroux a,cté b,guiral s,salem m,ducharme y,friesen rw,méthot n,mancini j,audoly l,riendeau d. mf63 [2-(6-chloro-1h-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin e synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. j pharmacol exp ther.2008 sep;326(3):754-63.

MF-63 Preparation Products And Raw materials

Raw materials

Preparation Products

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MF-63 Suppliers

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892549-43-8, MF-63Related Search:

MF-63

2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile

2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile

2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic

MF 63; MF-63

CS-2773

1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-

2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile

892549-43-8

C23H11ClN4