MF-63
- Product Name
- MF-63
- CAS No.
- 892549-43-8
- Chemical Name
- MF-63
- Synonyms
- MF-63;CS-2773;MF 63; MF-63;2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic;2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile;2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile;2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile;1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-
- CBNumber
- CB22512521
- Molecular Formula
- C23H11ClN4
- Formula Weight
- 378.81
- MOL File
- 892549-43-8.mol
MF-63 Property
- Boiling point:
- 709.7±70.0 °C(Predicted)
- Density
- 1.49
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 11.34±0.30(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 13217
- Product name
- MF63
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 13217
- Product name
- MF63
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 13217
- Product name
- MF63
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $183
- Updated
- 2024/03/01
- Product number
- 13217
- Product name
- MF63
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $371
- Updated
- 2024/03/01
- Product number
- 456183
- Product name
- MF 63
- Packaging
- 5mg
- Price
- $368
- Updated
- 2021/12/16
MF-63 Chemical Properties,Usage,Production
Description
Microsomal prostaglandin E2 synthase-
Uses
MF 63 is a microsomal prostaglandin E2 synthase-1 (mPGES-1) the final enzyme in the synthesis of PGE2. Prevents LPS-induced hyperglasia. Anti-inflammatory, analgesic, anti-cancer agent.
in vitro
mf63 was found to be significantly more potent than those previously reported mpges-1 inhibitors with an intrinsic inhibitory potency on the recombinant human mpges-1 enzyme. furthermore, mf63 showed a pge2 whole cell inhibition in a549 cells and a human whole blood activity [1].
in vivo
in rodent species, mf63 inhibited guinea pig mpges-1 strongly but not the mouse or rat enzyme. when tested in the guinea pig and a knock-in (ki) mouse expressing human mpges-1, mf63 suppressed the synthesis of pge2 selectively, but not other prostaglandins that were inhibitable by nonsteroidal anti-inflammatory drugs (nsaid), yet remaided nsaid-like efficacy at inhibiting lipopolysaccharide-induced hyperalgesia, pyresis, and iodoacetate-induced osteoarthritic pain. additionally, mf63 did not cause nsaid-like gastrointestinal toxic effects, such as mucosal erosions or leakage in the ki mice or nonhuman primates, although mf63 markedly inhibited pge2 synthesis in the ki mouse stomach [1].
IC 50
0.9 and 1.3 nm for pig mpges-1 and human mpges-1
References
[1] xu d,rowland se,clark p,giroux a,cté b,guiral s,salem m,ducharme y,friesen rw,méthot n,mancini j,audoly l,riendeau d. mf63 [2-(6-chloro-1h-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin e synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. j pharmacol exp ther.2008 sep;326(3):754-63.
MF-63 Preparation Products And Raw materials
Raw materials
Preparation Products
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