Methyl 3-(tert-butoxycarbonylamino)picolinate
- Product Name
- Methyl 3-(tert-butoxycarbonylamino)picolinate
- CAS No.
- 912369-42-7
- Chemical Name
- Methyl 3-(tert-butoxycarbonylamino)picolinate
- Synonyms
- Methyl 3-(BOC-amino)picolinate;Methyl 3-(tert-butoxycarbonyl)picolinate;Methyl 3-(Boc-amino)pyridine-2-carboxylate;Methyl 3-(tert-butoxycarbonylamino)picolinate;3-(tert-butyl) 2-methyl pyridine-2,3-dicarboxylate;methyl 3-{[(tert-butoxy)carbonyl]amino}pyridine-2-carboxylate;3-tert-Butoxycarbonylamino-pyridine-2-carboxylic acid methyl ester;Methyl 3-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-2-carboxylate;2-Pyridinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester
- CBNumber
- CB22513588
- Molecular Formula
- C12H16N2O4
- Formula Weight
- 252.27
- MOL File
- 912369-42-7.mol
Methyl 3-(tert-butoxycarbonylamino)picolinate Property
- Melting point:
- 94 °C(Solv: hexane (110-54-3))
- Boiling point:
- 339.9±27.0 °C(Predicted)
- Density
- 1.203±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- pka
- 12.32±0.70(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M330013
- Product name
- Methyl3-(BOC-amino)picolinate
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- V8978
- Product name
- Methyl3-(BOC-amino)picolinate
- Packaging
- 1g
- Price
- $163
- Updated
- 2021/12/16
- Product number
- CHM0393100
- Product name
- METHYL-3-((TERT-BUTOXYCARBONYL)AMINO)PICOLINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.38
- Updated
- 2021/12/16
- Product number
- V8978
- Product name
- Methyl3-(BOC-amino)picolinate
- Packaging
- 25g
- Price
- $1733
- Updated
- 2021/12/16
- Product number
- CD11018898
- Product name
- Methyl3-((tert-butoxycarbonyl)amino)picolinate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
Methyl 3-(tert-butoxycarbonylamino)picolinate Chemical Properties,Usage,Production
Synthesis
24195-07-1
75-65-0
912369-42-7
2-(Methoxycarbonyl)pyridine-3-carboxylic acid (3 g, 16.57 mmol) was dissolved in 50 mL of tert-butanol and triethylamine (4 mL) was added. After stirring at room temperature for 5 minutes, diphenylphosphoryl azide (3.6 mL, 16.57 mmol) was added and the reaction mixture was refluxed for 3 hours. Upon completion of the reaction, the mixture was concentrated and the residue was purified by fast column chromatography (silica gel) with ethyl acetate/cyclohexane (20% to 50% gradient) as eluent. The fraction containing the target product was collected and concentrated in vacuum to afford methyl 3-{[(tert-butoxy)carbonyl]amino}pyridine-2-carboxylate (1.6 g, 38.5% yield).
References
[1] Patent: WO2016/196776, 2016, A2. Location in patent: Paragraph 00765
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 9, p. 2754 - 2761
Methyl 3-(tert-butoxycarbonylamino)picolinate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 3-(tert-butoxycarbonylamino)picolinate Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44802
- Advantage
- 61
- Tel
- 21-54820552 18964669552
- Fax
- 086-21-64964478
- 188738128@qq.com
- Country
- China
- ProdList
- 310
- Advantage
- 66
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19906
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 027-87342388 18086026008
- Fax
- 027-87342388
- sales@kaymke.com
- Country
- China
- ProdList
- 3621
- Advantage
- 55
- Tel
- 0513-85921823 18662920231
- Fax
- 86-513-85012876
- sales@ntminyanmedical.com
- Country
- China
- ProdList
- 4206
- Advantage
- 58
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 21-33526724 18930996265
- Fax
- +86 21 37023730
- info@carlowchem.com
- Country
- China
- ProdList
- 1969
- Advantage
- 50
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52679
- Advantage
- 58