4-bromo-2-trifluoromethylphenylacetonitrile

Product Name: 4-bromo-2-trifluoromethylphenylacetonitrile
CAS No.: 877131-92-5
Chemical Name: 4-bromo-2-trifluoromethylphenylacetonitrile
Synonyms: 4-bromo-2-trifluoromethylphenylacetonitrile;Benzeneacetonitrile, 4-bromo-2-(trifluoromethyl)-;2-(4-BroMo-2-(trifluoroMethyl)phenyl)acetonitrile
CBNumber: CB22514727
Molecular Formula: C9H5BrF3N
Formula Weight: 264.04
MOL File: 877131-92-5.mol

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4-bromo-2-trifluoromethylphenylacetonitrile Property

storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B679180
Product name: 2-(4-Bromo-2-(trifluoromethyl)phenyl)acetonitrile
Packaging: 500mg
Price: $130
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3837-B-06
Product name: 4-Bromo-2-(trifluoromethyl)phenylacetonitrile
Packaging: 1g
Price: $184
Updated: 2021/12/16

Matrix Scientific

Product number: 119798
Product name: 2-(4-Bromo-2-(trifluoromethyl)phenyl)acetonitrile
Purity: 95+%
Packaging: 1g
Price: $288
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0362633
Product name: 2-(4-BROMO-2-(TRIFLUOROMETHYL)PHENYL)ACETONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $505.82
Updated: 2021/12/16

Matrix Scientific

Product number: 119798
Product name: 2-(4-Bromo-2-(trifluoromethyl)phenyl)acetonitrile
Purity: 95+%
Packaging: 5g
Price: $864
Updated: 2021/12/16

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4-bromo-2-trifluoromethylphenylacetonitrile Chemical Properties,Usage,Production

Synthesis

86845-27-4

151-50-8

877131-92-5

The general procedure for the synthesis of 4-bromo-2-trifluoromethylphenylacetonitrile from 5-bromo-2-methyltrifluorotoluene and potassium cyanide was as follows: 4-methyl-3-trifluorobromobenzene (33.26 g, 104.261 mmol), potassium cyanide (20.43 g, 313.67 mmol) and tetrabutylammonium bromide (3.37 g, 10.45 mmol) were reacted in a methylene chloride/water (1:1, 300 mL) in a solvent mixture of dichloromethane/water, and the reaction was stirred at room temperature for 4 hours. After the reaction was completed, the organic layer and the aqueous layer were separated, and the organic layer was washed with water (100 mL), 1N hydrochloric acid (100 mL), and saturated saline, and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to obtain a brown oily crude product. The crude product was purified by fast column chromatography (eluent: 0% to 20% hexane solution of ethyl acetate) to afford the target product 4-bromo-2-trifluoromethylphenylacetonitrile (14.9 g, 54% yield) in the form of a colorless transparent oil. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.91 (s, 2H), 7.57 (d, J = 8.3 Hz, 1H), 7.75 (dd, J = 8.3, 2Hz, 1H), 7.84 (d, J = 2Hz, 1H).

References

[1] Patent: WO2006/18725, 2006, A1. Location in patent: Page/Page column 208-209

4-bromo-2-trifluoromethylphenylacetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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877131-92-5, 4-bromo-2-trifluoromethylphenylacetonitrileRelated Search:

4-bromo-2-trifluoromethylphenylacetonitrile

2-(4-BroMo-2-(trifluoroMethyl)phenyl)acetonitrile

Benzeneacetonitrile, 4-bromo-2-(trifluoromethyl)-

877131-92-5