AZ 628

Product Name: AZ 628
CAS No.: 878739-06-1
Chemical Name: AZ 628
Synonyms: CS-70;AZ-628;AZD628;AZ628, >=99%;AZ628/AZ-628;cas 878739-06-1;AZ 628, 10 mM in DMSO;AZ-628;CAS 878739-06-1;AZ 628;AZ628;az628 DISCONTINUED, duplicate of A807000;AZ 628,Raf,inhibit,Inhibitor,AZ-628,AZ628,Raf kinases,Apoptosis
CBNumber: CB22516246
Molecular Formula: C27H25N5O2
Formula Weight: 451.52
MOL File: 878739-06-1.mol

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AZ 628 Property

Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble10mg/mL, clear
pka: 12.92±0.70(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-36/37/39-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0785
Product name: AZ628
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $73.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0785
Product name: AZ628
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $482
Updated: 2024/03/01

Cayman Chemical

Product number: 15336
Product name: AZ 628
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15336
Product name: AZ 628
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 15336
Product name: AZ 628
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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AZ 628 Chemical Properties,Usage,Production

Uses

AZ 628 is an inhibitor of B-RAF and B-RAF(V600E)

Definition

ChEBI: 3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxo-6-quinazolinyl)amino]phenyl]benzamide is a member of benzamides.

Biological Activity

az628 is a potent and newly discorvered inhibitor of braf, c-raf-1 and brafv600e with ic50 values of 105 nm, 29 nm and 34 nm, respectively. this compound prevents craf activation through persistently occupying the atp-binding site of raf kinase. specificity profile suggests that az628 also inhibits activation of other tyrosine protein kinases such as ddr2, vegfr2, lyn, flt1, fms and others.raf kinases a family of three serine/threonine-specific protein kinases and participate in the ras-raf-mek-erk signal transduction cascade, also known as the mitogen-activated protein kinase (mapk) cascade. the activation of mapk signaling leads to different cellular response such as cell proliferation, apoptosis and inflammation.az628 has the potent anti-tumor activity. in human colon and melanoma-derived cell line that carries the recurrent v600e activating braf mutation, az628 was shown to inhibit anchorage-dependent and -independent growth, induce cell cycle arrest, and cause apoptosis [1]. az628 may be antiangiogenic due to inhibition of vegfr2 [2].generation of melanoma cell line clones is obtained resistance to the raf kinase inhibitor az628. resistance to az628 is connected with raised levels of the raf downstream effector p-erk1/2. erk1/2 initiation in az628-resistant clones is interceded by mek. supported multiplication of az628-resistant clones is to a great extent autonomous of braf kinase action. az628-resistant clones express elevated craf. survival of az628-safe cells is subject to craf [1].

in vitro

AZ628 inhibits B-Raf, B-Raf AZ628 acts on B-Raf-containing M14 parental cell lines treated with increasing concentrations of AZ628, an effective inhibition of p-ERK1/2 levels was observed. It acts on AZ628-resistant M14 cells and does not inhibit ERK activation. AZ628 acts on NRAS-mutated malignant melanoma cells and effectively reduces ERK activation.

target

Target	Value
C-Raf-1 (Cell-free assay)	29 nM
B-Raf (V600E) (Cell-free assay)	34 nM
B-Raf (Cell-free assay)	105 nM

storage

Store at +4°C

References

1. montagut c, sharma sv, shioda t, mcdermott u, ulman m, ulkus le, et al. elevated craf as a potential mechanism of acquired resistance to braf inhibition in melanoma. cancer res 2008,68:4853-4861.2. khazak v, astsaturov i, serebriiskii ig, golemis ea. selective raf inhibition in cancer therapy. expert opin ther targets 2007,11:1587-1609.

AZ 628 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ 628 Suppliers

China 98 India 1 United Kingdom 2 United States 20 Global 121

AdooQ BioScience, LLC

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Target molecule Corp.

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Cckinase, Inc.

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Aladdin Scientific

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TargetMol Chemicals Inc.

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View Lastest Price from AZ 628 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: AZ 628 878739-06-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

878739-06-1, AZ 628Related Search:

Selumetinib TAK-632 Tozasertib Trametinib GDC-0879 PLX4032

3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide

AZ-628

AZ628/AZ-628

AZD628

3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide

AZ628, >=99%

3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)ben

Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-

3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)

AZ-628;CAS 878739-06-1;AZ 628;AZ628

cas 878739-06-1

CS-70

az628 DISCONTINUED, duplicate of A807000

AZ 628,Raf,inhibit,Inhibitor,AZ-628,AZ628,Raf kinases,Apoptosis

AZ 628, 10 mM in DMSO

878739-06-1

Inhibitors

MAPK