4-Bromo-3-chloro-7-methoxyquinoline
- Product Name
- 4-Bromo-3-chloro-7-methoxyquinoline
- CAS No.
- 1208452-88-3
- Chemical Name
- 4-Bromo-3-chloro-7-methoxyquinoline
- Synonyms
- 4-Bromo-3-chloro-7-methoxyquinoline;Quinoline, 4-bromo-3-chloro-7-methoxy-
- CBNumber
- CB22517076
- Molecular Formula
- C10H7BrClNO
- Formula Weight
- 272.53
- MOL File
- 1208452-88-3.mol
4-Bromo-3-chloro-7-methoxyquinoline Property
- Boiling point:
- 358.8±37.0 °C(Predicted)
- Density
- 1.613±0.06 g/cm3(Predicted)
- form
- solid
- pka
- 1.29±0.38(Predicted)
- color
- Light brown
- InChI
- InChI=1S/C10H7BrClNO/c1-14-6-2-3-7-9(4-6)13-5-8(12)10(7)11/h2-5H,1H3
- InChIKey
- AXUVEBXTLZJXMK-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=C(OC)C=2)C(Br)=C(Cl)C=1
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
4-Bromo-3-chloro-7-methoxyquinoline Chemical Properties,Usage,Production
Synthesis
A method for synthesizing 4-bromo-3-chloro-7-methoxyquinoline comprises the following steps:
the first step is as follows: synthesis of 3-chloro-4-hydroxy-7-methoxyquinoline
Adding tetrahydrofuran (300 g), N, N-dimethylformamide (5g) and 4-hydroxy-7-methoxyquinoline (50.0 g and 0.29 mol) into a reaction bottle in sequence, stirring and dissolving, adding N-chlorosuccinimide (NCS) (38.74 g and 0.68 mol), stirring and dissolving, reacting for 2 hours at 33 ℃ until yellow solid is generated, filtering, and drying to obtain 50.43g of a 3-chloro-4-hydroxy-7-methoxyquinoline product;
the second step is that: synthesis of 4-bromo-3-chloro-7-methoxyquinoline
Acetonitrile (500g) and 3-chloro-4-hydroxy-7-methoxyquinoline (50g, 0.24mol) are sequentially added into a reaction bottle at room temperature, stirred and dissolved, the temperature is reduced to-2 ℃, tribromooxyphosphorus (172.01 g,0.6 mol) is added, the temperature is raised after the addition, the reaction is carried out for 30 minutes at 5 ℃, the reaction is carried out for 15 hours at 55 ℃, brown solid is generated, suction filtration is carried out to obtain solid, the solid is poured into ice water for dissolution, the solution is adjusted to the PH value being not less than 7 by using potassium carbonate, the solid is separated out, suction filtration, water washing and drying are carried out to obtain 58.86g of a finished product of the 4-bromo-3-chloro-7-methoxyquinoline.
4-Bromo-3-chloro-7-methoxyquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-3-chloro-7-methoxyquinoline Suppliers
- Tel
- 18696571988
- Fax
- +86 (23) 6777-0220
- amy.lei@chemieliva.com
- Country
- China
- ProdList
- 1561
- Advantage
- 60
- Tel
- 0512-69209928;68417696 18306209966;13962195629
- linda@highfine.com;minhan.zhao@highfine.com
- Country
- China
- ProdList
- 1639
- Advantage
- 58
- Tel
- 28-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 510
- Advantage
- 57
- Tel
- 0512-62857507
- Fax
- +86-512-62857507
- sales@sinorarechem.com
- Country
- China
- ProdList
- 997
- Advantage
- 58
- Tel
- +86-021-50890968，021-50891159 +86-18601776121
- Fax
- 086-21-68416099 58604179
- danny@urchem.com
- Country
- China
- ProdList
- 635
- Advantage
- 58
- Tel
- +86-021-58380978 13482386415
- Fax
- 021-58380978
- info@systeambc.com
- Country
- China
- ProdList
- 896
- Advantage
- 50
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 8556
- Advantage
- 58
- Tel
- 0531-61320525 15866703830
- figo.gao@foxmail.com
- Country
- China
- ProdList
- 6673
- Advantage
- 58
- Tel
- 029-88380327 17691182729
- Fax
- 029-88380327
- 1018@dideu.com
- Country
- China
- ProdList
- 2011
- Advantage
- 58
- Tel
- 021-544580828 021-54450828
- sales@fwdchem.com
- Country
- China
- ProdList
- 997
- Advantage
- 58
View Lastest Price from 4-Bromo-3-chloro-7-methoxyquinoline manufacturers
- Product
- 4-Bromo-3-chloro-7-methoxyquinoline 1208452-88-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2025-09-16
- Product
- 4-Bromo-3-chloro-7-methoxyquinoline 1208452-88-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-05-09