METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE

Product Name: METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE
CAS No.: 35761-27-4
Chemical Name: METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE
Synonyms: Z-Dap-OMe.HCl;Z-L-Dap-OMe*HCl;CBZ-Dap-OMe.HCl;3-Amino-N-Cbz-L-alanine methyl ester HCl;Methyl 2-(S)-[N-Carbobenzyloxy]amino-3-aminopropionate;benzyl (S)-1-(methoxycarbonyl)-2-aminoethylcarbamate HCl;Methyl (S)-3-Amino-2-(Cbz-amino)propanoate Hydrochloride;3-Amino-N-[(phenylmethoxy)carbonyl]-L-alanine methyl ester;Methyl 2-(s)-[n-carbobenzyloxy]amino-3-aminopropionate, HCl;3-Amino-N-(benzyloxycarbonyl)-L-alanine methyl ester hydrochloride
CBNumber: CB2251802
Molecular Formula: C12H17ClN2O4
Formula Weight: 288.73
MOL File: 35761-27-4.mol

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METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE Property

Melting point:: 157-162°C dec.
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform, Methanol
form: Solid
color: White
optical activity: Consistent with structure

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M294430
Product name: Methyl2-(S)-[N-Carbobenzyloxy]amino-3-aminopropionate,Hydrochloride
Packaging: 1g
Price: $130
Updated: 2021/12/16

Chem-Impex

Product number: 26448
Product name: Nα-Z-L-2,3-diaminopropionicacidmethylesterhydrochloride,98.5%(HPLC)
Purity: 98.5%(HPLC)
Packaging: 250MG
Price: $44.8
Updated: 2021/12/16

Chem-Impex

Product number: 26448
Product name: Nα-Z-L-2,3-diaminopropionicacidmethylesterhydrochloride,≥98.5%(HPLC)
Purity: ≥98.5%(HPLC)
Packaging: 1G
Price: $99.01
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ZAA1270
Product name: Z-L-Dap-OMe*HCl
Packaging: 1g
Price: $135
Updated: 2021/12/16

Activate Scientific

Product number: AS49937
Product name: Z-L-Dap-OMe HCl
Purity: 95% ee
Packaging: 1g
Price: $160
Updated: 2021/12/16

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METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins.

Synthesis

75760-11-1

35761-27-4

General procedure for the synthesis of methyl (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoate hydrochloride from compound (CAS: 75760-11-1): 3-amino-N-[(benzyloxy)carbonyl]-L-alanine methyl ester (5.0 g, 21.0 mmol) and anhydrous methanol (100 mL) were added to a flask fitted with a magnetic stir bar. HCl gas was passed into the solution/slurry for about 10 minutes under stirring conditions. After about 2 minutes, an exothermic reaction was observed and the solution changed from turbid white to clear/colorless. After stirring the reaction solution overnight, it was concentrated and dried by vacuum to afford methyl (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propionate hydrochloride (6.0 g, 98% yield) as white crystals.1H NMR (δ): 3.05 (t, 1H), 3.19 (t, 1H), 3.70 (s, 3H), 4.45 (m, 1H), 5.10 ( s, 2H), 7.38 (m, 5H), 7.95 (d, 1H), 8.35 (br s, 3H).LCMS (ES, M + H = 253).

References

[1] Patent: WO2006/106326, 2006, A1. Location in patent: Page/Page column 99

METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE Suppliers

Canada 1 China 49 France 1 Germany 1 India 2 Japan 2 United Kingdom 1 United States 8 Global 65

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35761-27-4, METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDERelated Search:

Z-LYS(AC)-NH2 N-Cbz-L-glutamic acid 5-ethyl ester Z-LEU-TRP-OH Z-DAB(BOC)-OH Z-Dap(Alloc).DCHA Z-D-Dap-OMe.HCl Z-D-DAP(FMOC)-OH Z-D-Dap(Alloc).DCHA (2R)-4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid Z-D-DAB(BOC)-OH DCHA (2S)-4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-[[(phenylmethoxy)carbonyl]amino]butanoic acid

METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE

METHYL 2-(S)-[N-(BENZYLOXY)CARBONYL]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE

3-Amino-N-Cbz-L-alanine methyl ester HCl

methyl (2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoate hydrochloride

3-Amino-N-[(phenylmethoxy)carbonyl]-L-alanine methyl ester

Methyl 2-(S)-[N-Carbobenzyloxy]amino-3-aminopropionate

3-AMino-N-[(phenylMethoxy)carbonyl]-L-alanine Methyl Ester Hydrochloride

Z-Dap-OMe.HCl

Z-L-Dap-OMe*HCl

Nα-Z-L-2,3-diaminopropionic acid methyl ester hydrochloride≥ 98.5% (HPLC)

methyl (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoate hydrochloride

3-Amino-N-(benzyloxycarbonyl)-L-alanine methyl ester hydrochloride

benzyl (S)-1-(methoxycarbonyl)-2-aminoethylcarbamate HCl

METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE USP/EP/BP

N-α-Carbobenzoxy-L-α,β-diaminopropionic acid methyl ester hydrochloride

(2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropan-1-aminium chloride

Methyl 2-(s)-[n-carbobenzyloxy]amino-3-aminopropionate, HCl

methyl (2S)-3-amino-2-(phenylmethoxycarbonylamino)propanoate,hydrochloride

CBZ-Dap-OMe.HCl

Methyl (S)-3-Amino-2-(Cbz-amino)propanoate Hydrochloride

35761-27-4

C12H17ClN2O4

Amino Acids & Derivatives

amino acids