AZD8931
- Product Name
- AZD8931
- CAS No.
- 848942-61-0
- Chemical Name
- AZD8931
- Synonyms
- CS-368;AZD8931;Sapitinib;AZD8931, >=96%;AZD8931 USP/EP/BP;Sapitinib(AZD8931);AZD8931 (Sapitinib);AZD-8931;AZD8931;AZD 8931;AZD8931 (SAPITINIB);AZD 8931;2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinaz...
- CBNumber
- CB22518215
- Molecular Formula
- C23H25ClFN5O3
- Formula Weight
- 473.93
- MOL File
- 848942-61-0.mol
AZD8931 Property
- Boiling point:
- 632.8±55.0 °C(Predicted)
- Density
- 1.339
- storage temp.
- Store at -20°C
- solubility
- ≥23.7 mg/mL in DMSO; insoluble in H2O; ≥57.8 mg/mL in EtOH with gentle warming
- form
- solid
- pka
- 16.17±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P314Get medical advice/attention if you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 24196
- Product name
- AZD 8931
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 24196
- Product name
- AZD 8931
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $140
- Updated
- 2024/03/01
- Product number
- 24196
- Product name
- AZD 8931
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $235
- Updated
- 2024/03/01
- Product number
- 24196
- Product name
- AZD 8931
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- A8375
- Product name
- AZD8931(Sapitinib)
- Packaging
- 50mg
- Price
- $599
- Updated
- 2021/12/16
AZD8931 Chemical Properties,Usage,Production
Uses
AZD8931 is a novel potent reversible small molecule epidermal growth factor receptor, ERBB2 (HER2) and ERBB3 inhibitor with an IC50 of 4, 3, 4 nM, respectively.
Definition
ChEBI: A member of the class of quinazolines that is 4-amino-7-methoxyquinazoline in which the amino group has been substituted by a 3-chloro-2-fluorophenyl group and in which position 6 of the quinoline ring has been substituted by a {1-[2-(methylamino)-2-oxoeth l]piperidin-4-yl}oxy group. Sapitinib is a dual tyrosine kinase inhibitor (TKI) of epithelial growth factor receptors (EGFR) HER2 and HER3.
Enzyme inhibitor
This signal transduction kinase inhibitor (FW = 473.94 g/mol; CAS 848942-61-0), also named 2-(4-[4-(3-chloro-2-fluorophenylamino)-7- methoxyquinazolin-6-yloxy]piperidin-1-yl)-N-methylacetamide, reversibly inhibits EGFR (IC50 = 4 nM), erbB2 (IC50 = 3 nM), and erbB3 (IC50 = 4 nM) phosphorylation in cells. In proliferation assays, AZD8931 is significantly more potent than gefitinib or lapatinib in specific squamous cell carcinoma of the head and neck and non-small cell lung carcinoma cell lines. In vivo, AZD8931 inhibits xenograft growth in a range of models, while significantly affecting EGFR, erbB2, and erbB3 phosphorylation and downstream signaling pathways, apoptosis, and proliferation. In EGF and HRG ligand-driven cell systems, AZD8931 is more potent than gefitinib or lapatinib. Metabolic disposition of AZD8931.
target
ErbB2
AZD8931 Preparation Products And Raw materials
Raw materials
Preparation Products
AZD8931 Suppliers
View Lastest Price from AZD8931 manufacturers
- Product
- AZD8931 848942-61-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-09
- Product
- Sapitinib 848942-61-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Sapitinib 848942-61-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09