ChemicalBook > CAS DataBase List > N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride

N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride

Product Name
N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride
CAS No.
1186195-62-9
Chemical Name
N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride
Synonyms
IKK 16;CS-933;IKK-16 HCl;IKK16/IKK-16;IKK 16, >=98%;IKK-16 (hydrochloride);IKK-16 (hydrochloride) NEW;IKK-16, IkappaB kinase inhibitor;(4-((4-(Benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone hydrochloride;N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride
CBNumber
CB22518699
Molecular Formula
C28H31ClN6OS
Formula Weight
535.10334
MOL File
1186195-62-9.mol
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N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
≤10mg/ml in DMSO;5mg/ml in dimethyl formamide
form 
crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13313
Product name
IKK-16 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
13313
Product name
IKK-16 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
13313
Product name
IKK-16 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$412
Updated
2024/03/01
Cayman Chemical
Product number
13313
Product name
IKK-16 (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$728
Updated
2024/03/01
Tocris
Product number
2539
Product name
IKK16
Purity
≥98%(HPLC)
Packaging
50
Price
$1071
Updated
2021/12/16
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N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride Chemical Properties,Usage,Production

Uses

IKK-16 Hydrochloride is a potential novel IκB kinase 2 (IKK2) inhibitor used in the treatment of various immune/inflammatory disorders.

Biological Activity

ikk-16 is an iκb kinases (ikks) inhibitor.the iκb kinase (ikk), part of a high molecular weight protein complex consisting of three subunits, ikk1, ikk2, and ikkc, emerged as a prime target for the development of novel anti-rheumatic and anti-inflammatory drugs.

in vitro

in screening study, it was found that compounds with an additional basic amino group were more active than the neutral inhibitors. the tertiary amines, such as ikk-16, was active in the low-nanomolar range. ikk-16 could inhibit tnfa-induced adhesion molecule expression in a potency range similar to the ijba degradation. although ikk-16 showed activity in the ifnc-induced expression of b2 microglobulin, its potency was weaker. these data demonstrated that ikk-16 had an effect on downstream gene expression, however, on the cellular level the selectivity was modest [1].

in vivo

animal study found that the treatment with ikk 16 to mice could attenuate the impairment in systolic contractility, renal dysfunction, hepatocellular injury and lung inflammation in lps/pepg-induced mod and in polymicrobial sepsis. ikk-16 treatment could also significantly attenuated the increase in inducible nitric oxide synthase (inos) expression and increase the phosphorylation of akt and endothelial nitric oxide synthase [2].

IC 50

200, 40, and 70 nm for ikkα, ikkβ, and ikk complex, respectively.

storage

Desiccate at -20°C

References

[1] waelchli, r. ,bollbuck, b.,bruns, c., et al. design and preparation of 2-benzamido-pyrimidines as inhibitors of ikk. bioorganic & medicinal chemistry letters 16(1), 108-112 (2006).
[2] coldewey, s. m.,rogazzo, m.,collino, m., et al. inhibition of i k b kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. dis.model mech. 6, 1031-1042 (2013).

N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride Suppliers

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1186195-62-9, N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochlorideRelated Search:


  • IKK 16
  • N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride
  • IKK16/IKK-16
  • [4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone hydrochloride (1:1)
  • IKK 16, >=98%
  • IKK-16 (hydrochloride)
  • IKK-16 HCl
  • CS-933
  • Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-, hydrochloride (1:1)
  • (4-((4-(Benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone hydrochloride
  • IKK-16 (hydrochloride) NEW
  • IKK-16, IkappaB kinase inhibitor
  • 1186195-62-9
  • C28H29N5OSHCl