2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
- Product Name
- 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
- CAS No.
- 177172-49-5
- Chemical Name
- 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
- Synonyms
- R-568;NPS-R568;R 568 hydrochloride;Tecalcet HCl (KRN568;Tecalcet (Hydrochloride);R-568 hydrochloride >=95% (HPLC);Tecalcet Hydrochloride, 10 mM in DMSO;2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride;(R)-3-(2-Chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine hydrochloride;3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, hydrochloride
- CBNumber
- CB22518826
- Molecular Formula
- C18H23Cl2NO
- Formula Weight
- 340.28732
- MOL File
- 177172-49-5.mol
2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride Property
- Melting point:
- 183.3-184.4 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO : 50 mg/mL (146.93 mM; Need ultrasonic)
- form
- Powder
- color
- White to off-white
- optical activity
- [α]/D +35 to +40°, c =0.5 in chloroform-d
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17415
- Product name
- R-568
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 17415
- Product name
- R-568
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- 17415
- Product name
- R-568
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 17415
- Product name
- R-568
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $704
- Updated
- 2024/03/01
- Product number
- 3815
- Product name
- R568hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $166
- Updated
- 2021/12/16
2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride Chemical Properties,Usage,Production
Description
Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. R-568 is a calcimimetic compound that can allosterically activate or positively modulate the human CaSR. It dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials. R-568 is used in research to explore novel actions of CaSR.
Uses
Treatment of hyperparathyroidism and related disorders, such as hypercalcemia (reduction of PTH secretion through modulation of calcium ion receptors on parathyroid cells).
Uses
R 568 Hydrochloride is a calcimimetic, which prevents vascular remodeling in uremia.
brand name
Norcalcin (Amgen).
in vivo
Tecalcet (1.5 and 15 mg/kg, orally, twice daily for 4 days) inhibits PT cell proliferation in rats with renal insufficiency[1].
| Animal Model: | 10-wk-old Male Sprague-Dawley rats weighing 310-350 g[1]. |
| Dosage: | 1.5 and 15 mg/kg. |
| Administration: | Orally twice daily for 4 days. |
| Result: | Did not significantly change serum 1,25 (OH)2D3 levels. In contrast, serum PTH levels were reduced by in a dose-dependent manner. Clearly reduced the number of BrdU-positive PT cells by 20% at a low dose (1.5 mg/kg body wt), and by 50% at a high dose (15 mg/kg body wt), indicating an antiproliferative effect on PT cells. Reduced PT cell volume in a dose-dependent manner. |
storage
Desiccate at RT
References
[1] E F NEMETH. Calcimimetics with potent and selective activity on the parathyroid calcium receptor.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95 7: 4040-4045. DOI: 10.1073/pnas.95.7.4040
[2] J FOX. NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 290 2: 473-479.
[3] M WADA. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor.[J]. Journal of Clinical Investigation, 1997, 100 12: 2977-2983. DOI: 10.1172/jci119851
2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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