2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
- Product Name
- 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
- CAS No.
- 177172-49-5
- Chemical Name
- 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
- Synonyms
- R-568;NPS-R568;R 568 hydrochloride;Tecalcet HCl (KRN568;Tecalcet (Hydrochloride);R-568 hydrochloride >=95% (HPLC);2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride;(R)-3-(2-Chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine hydrochloride;3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, hydrochloride;Benzenepropanamine, 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-, hydrochloride (1:1)
- CBNumber
- CB22518826
- Molecular Formula
- C18H23Cl2NO
- Formula Weight
- 340.28732
- MOL File
- 177172-49-5.mol
2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride Property
- Melting point:
- 183.3-184.4 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO : 50 mg/mL (146.93 mM; Need ultrasonic)
- form
- Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17415
- Product name
- R-568
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 17415
- Product name
- R-568
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- 17415
- Product name
- R-568
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 17415
- Product name
- R-568
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $704
- Updated
- 2024/03/01
- Product number
- 3815
- Product name
- R568hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $166
- Updated
- 2021/12/16
2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride Chemical Properties,Usage,Production
Description
Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. R-568 is a calcimimetic compound that can allosterically activate or positively modulate the human CaSR. It dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials. R-568 is used in research to explore novel actions of CaSR.
Uses
Treatment of hyperparathyroidism and related disorders, such as hypercalcemia (reduction of PTH secretion through modulation of calcium ion receptors on parathyroid cells).
Uses
R 568 Hydrochloride is a calcimimetic, which prevents vascular remodeling in uremia.
brand name
Norcalcin (Amgen).
storage
Desiccate at RT