6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid

Product Name: 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid
CAS No.: 345952-44-5
Chemical Name: 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid
Synonyms: MM 11253;MM 11253, RARgamma;MM11253 >=98% (HPLC);MM 11253, 10 mM in DMSO;6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid;6-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid;2-Naphthalenecarboxylic acid, 6-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-
CBNumber: CB22518886
Molecular Formula: C28H30O2S2
Formula Weight: 462.67
MOL File: 345952-44-5.mol

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6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid Property

Boiling point:: 607.8±55.0 °C(Predicted)
Density: 1.202
storage temp.: Desiccate at RT
solubility: DMSO: 30 mg/ml
form: A solid
pka: 4.12±0.30(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2015
Product name: MM11253
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $131
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2015
Product name: MM11253
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $425
Updated: 2024/03/01

Cayman Chemical

Product number: 21800
Product name: MM-11253
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 21800
Product name: MM-11253
Purity: ≥98%
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 21800
Product name: MM-11253
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid Chemical Properties,Usage,Production

Uses

MM-11253 is a synthetic retinoid and a selective RARγ antagonist.

Biological Activity

MM11253 (SR11253) is a high-affinity RARγ-selective retinoid acid (RA) receptor antagonist (IC50 = 44 nM against ATRA for binding RARγ; IC50 =1 μM in case of RARα, RARβ, RXRα) th at prevents >90% growth inhibitory effect of retinoids AHPN/CD437 (1 μM in CA-OV3 & SK-SKOV3 cultures) and M11389 (1 μM in SCC-25 squamous cell carcinoma cultures) when used at equal concentration. MM11253 also effectively blocks the inhibitory effect of R667 (RARγ agonist) against IL-1β-induced MMP production from rabbit corneal fibroblasts (80% vs. 11% inhibition by 0,1 nM R667, respectively, without or with 0.03 nM MM11253).

storage

Desiccate at RT

6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid Suppliers

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345952-44-5, 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacidRelated Search:

6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid

MM 11253

MM11253 >=98% (HPLC)

6-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid

2-Naphthalenecarboxylic acid, 6-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-

MM 11253, RARgamma

MM 11253, 10 mM in DMSO

345952-44-5

C28H30O2S2