ChemicalBook > CAS DataBase List > 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid

6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid

Product Name
6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid
CAS No.
345952-44-5
Chemical Name
6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid
Synonyms
MM 11253;MM 11253, RARgamma;MM11253 >=98% (HPLC);MM 11253, 10 mM in DMSO;6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid;6-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid;2-Naphthalenecarboxylic acid, 6-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-
CBNumber
CB22518886
Molecular Formula
C28H30O2S2
Formula Weight
462.67
MOL File
345952-44-5.mol
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6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid Property

Boiling point:
607.8±55.0 °C(Predicted)
Density 
1.202
storage temp. 
Desiccate at RT
solubility 
DMSO: 30 mg/ml
form 
A solid
pka
4.12±0.30(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2015
Product name
MM11253
Purity
≥98% (HPLC)
Packaging
5MG
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2015
Product name
MM11253
Purity
≥98% (HPLC)
Packaging
25MG
Price
$425
Updated
2024/03/01
Cayman Chemical
Product number
21800
Product name
MM-11253
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
21800
Product name
MM-11253
Purity
≥98%
Packaging
5mg
Price
$111
Updated
2024/03/01
Cayman Chemical
Product number
21800
Product name
MM-11253
Purity
≥98%
Packaging
10mg
Price
$184
Updated
2024/03/01
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6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid Chemical Properties,Usage,Production

Uses

MM-11253 is a synthetic retinoid and a selective RARγ antagonist.

Biological Activity

MM11253 (SR11253) is a high-affinity RARγ-selective retinoid acid (RA) receptor antagonist (IC50 = 44 nM against ATRA for binding RARγ; IC50 =1 μM in case of RARα, RARβ, RXRα) th at prevents >90% growth inhibitory effect of retinoids AHPN/CD437 (1 μM in CA-OV3 & SK-SKOV3 cultures) and M11389 (1 μM in SCC-25 squamous cell carcinoma cultures) when used at equal concentration. MM11253 also effectively blocks the inhibitory effect of R667 (RARγ agonist) against IL-1β-induced MMP production from rabbit corneal fibroblasts (80% vs. 11% inhibition by 0,1 nM R667, respectively, without or with 0.03 nM MM11253).

storage

Desiccate at RT

6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid Suppliers

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345952-44-5, 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacidRelated Search:


  • 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid
  • MM 11253
  • MM11253 >=98% (HPLC)
  • 6-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid
  • 2-Naphthalenecarboxylic acid, 6-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-
  • MM 11253, RARgamma
  • MM 11253, 10 mM in DMSO
  • 345952-44-5
  • C28H30O2S2