ChemicalBook > CAS DataBase List > 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
- Product Name
- 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
- CAS No.
- 64232-83-3
- Chemical Name
- 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
- Synonyms
- L189;L 189;L189;(E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone;6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone;4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-
- CBNumber
- CB22518932
- Molecular Formula
- C11H10N4OS
- Formula Weight
- 246.29
- MOL File
- 64232-83-3.mol
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6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Property
- Melting point:
- 250 °C (decomp)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- ≥62.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- form
- solid
- pka
- 8.16±0.60(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 18374
- Product name
- L189
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18374
- Product name
- L189
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18374
- Product name
- L189
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $379
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18374
- Product name
- L189
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $546
- Updated
- 2024/03/01
Tocris
- Product number
- 3561
- Product name
- L189
- Packaging
- 10
- Price
- $181
- Updated
- 2021/12/16
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6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Chemical Properties,Usage,Production
Description
L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 μM, respectively). It blocks DNA binding (Ki = 5 μM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.
Uses
L189 has been shown to inhibit DNA ligases I, III, and IV and may have potential use in the development of anticancer agents.
storage
Store at -20°C
References
[1]. xi chen, shijun zhong, xiao zhu, et al. rational design of human dna ligase inhibitors that target cellular dna replication and repair. cancer res., 2008, 68(9): 3169-3177.
[2]. mark r. taylor, john a. conrad, daniel wahl, et al. kinetic mechanism of human dna ligase i reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency. journal of biological chemistry, 2011, 286(26): 23054-23062.
[3]. christian jekimovs, emma bolderson, amila suraweera, et al. chemotherapeutic compounds targeting the dna double-strand break repair pathways: the good, the bad, and the promising. frontiers in oncology, 2014, 4: article 86.
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Preparation Products And Raw materials
Raw materials
Preparation Products
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