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Steppogenin

Product Name
Steppogenin
CAS No.
56486-94-3
Chemical Name
Steppogenin
Synonyms
Steppogenin;norartocarpanone;2',4',5,7-Tetrahydroxyflavanone;4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2S)-
CBNumber
CB22520025
Molecular Formula
C15H12O6
Formula Weight
288.25
MOL File
56486-94-3.mol
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Steppogenin Property

solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
color 
White to off-white
InChI
InChI=1S/C15H12O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-5,13,16-19H,6H2/t13-/m0/s1
InChIKey
QBLQLKNOKUHRCH-ZDUSSCGKSA-N
SMILES
[C@H]1(C2=CC=C(O)C=C2O)OC2=CC(O)=CC(O)=C2C(=O)C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

CSNpharm
Product number
CSN14818
Product name
Steppogenin
Packaging
1mg
Price
$393
Updated
2021/12/16
Arctom
Product number
CFN98949
Product name
Steppogenin
Packaging
5mg
Price
$413
Updated
2021/12/16
Crysdot
Product number
CD32000970
Product name
Steppogenin
Purity
95+%
Packaging
5mg
Price
$860
Updated
2021/12/16
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Steppogenin Chemical Properties,Usage,Production

Uses

Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively. Steppogenin can be sued for the research of angiogenic diseases, such as those involving solid tumors[1].

in vivo

Steppogenin (2 mg/kg, IP, once) inhibits tumor growth and angiogenesis[1].
Steppogenin (2 mg/kg, IP, once) shows the highest distribution to the liver and spleen (25.5-fold and 9.74-fold AUC ratio, respectively) with significantly higher T1/2[1].
Pharmacokinetic Parameters of Steppogenin in male C57BL/6 J mice[1].

Cmax (ng/mL)Tmax (h)T1/2 (h)AUC8h (ng/mL?h)AUC∞ (ng/mL?h)AUC ratio
Plasma448 ± 1130.250.49 ± 0.14283 ± 98.9284 ± 97.81
Tumor635 ± 1140.3 ± 0.11.87 ± 0.871078 ± 4941252 ± 5474.58
Liver4319 ± 10630.251.72 ± 0.266733 ± 13006967 ± 120025.5
Lung521 ± 1810.250.36 ± 0.12261 ± 96.1280 ± 1061.02
Heart285 ± 15.20.250.2107 ± 44.3176.90.65
Kidney1225 ± 4630.250.33 ± 0.01628 ± 234624.7 ± 2382.35
Spleen6110 ± 29540.250.47 ± 0.012443 ± 11552663 ± 12899.74
Brain309 ± 95.70.251.36 ± 0.46191 ± 67241 ± 75.40.88
Animal Model:C57BL/6 J mice (6-week-old, male, Lewis lung carcinoma (LLC) allograft tumor model)[1]
Dosage:2 mg/kg
Administration:IP, once
Result:Significantly suppressed tumor growth.
Animal Model:C57BL/6 J mice (6-week-old, male, Lewis lung carcinoma (LLC) allograft tumor model)[1]
Dosage:2 mg/kg
Administration:IP, once (Pharmacokinetic Analysis)
Result:Showed the highest distribution to the liver and spleen (25.5-fold and 9.74-fold AUC ratio, respectively) with significantly higher T1/2. may not be accumulated even in the highly distributed tissues after the repeated administration of steppogenin.

target

Tyrosinase

References

[1] Cha S, et al. Steppogenin suppresses tumor growth and sprouting angiogenesis through inhibition of HIF-1α in tumors and DLL4 activity in the endothelium. Phytomedicine. 2023 Jan;108:154513. DOI:10.1016/j.phymed.2022.154513

Steppogenin Preparation Products And Raw materials

Raw materials

Preparation Products

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Steppogenin Suppliers

China 42 United States 2 USA 1 Global 45
Chengdu Alfa Biotechnology Co.,Ltd.
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Aikon International Limited
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56486-94-3, SteppogeninRelated Search:


  • Steppogenin
  • 2',4',5,7-Tetrahydroxyflavanone
  • 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2S)-
  • norartocarpanone
  • 56486-94-3