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Smad3 Inhibitor, SIS3

Product Name
Smad3 Inhibitor, SIS3
CAS No.
1009104-85-1
Chemical Name
Smad3 Inhibitor, SIS3
Synonyms
SIS3 free base;Smad3 Inhibitor;(Rac)-SIS3 free base;SMAD3 Inhibtor, SIS 3;Smad3 Inhibitor, SIS3;SIS-3 free base,SIS3 free base;(E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-3-pyrrolo[2,3-b]pyridyl)-2-propen-1-one;1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-
CBNumber
CB22520818
Molecular Formula
C28H27N3O3
Formula Weight
453.53
MOL File
1009104-85-1.mol
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Smad3 Inhibitor, SIS3 Property

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.2 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15945
Product name
SMAD3 Inhibitor, SIS3
Purity
≥98%
Packaging
500μg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
15945
Product name
SMAD3 Inhibitor, SIS3
Purity
≥98%
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
15945
Product name
SMAD3 Inhibitor, SIS3
Purity
≥98%
Packaging
5mg
Price
$380
Updated
2024/03/01
TRC
Product number
S564500
Product name
SMAD3Inhibtor,SIS3
Packaging
2.5mg
Price
$130
Updated
2021/12/16
TRC
Product number
S564500
Product name
SMAD3Inhibtor,SIS3
Packaging
5mg
Price
$205
Updated
2021/12/16
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Smad3 Inhibitor, SIS3 Chemical Properties,Usage,Production

Uses

SMAD3 Inhibitor, SIS3 selectively inhibits TGF-β and activin. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

Definition

ChEBI: An enamide resulting from the formal condensation of the amino group of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline with the carboxy group of (2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acrylic cid.

Smad3 Inhibitor, SIS3 Preparation Products And Raw materials

Raw materials

Preparation Products

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Smad3 Inhibitor, SIS3 Suppliers

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1009104-85-1, Smad3 Inhibitor, SIS3Related Search:

Smad3 Inhibitor

  • Smad3 Inhibitor
  • Smad3 Inhibitor, SIS3
  • SIS3 free base
  • SMAD3 Inhibtor, SIS 3
  • (E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-3-pyrrolo[2,3-b]pyridyl)-2-propen-1-one
  • 2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-
  • SIS-3 free base,SIS3 free base
  • 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one
  • (Rac)-SIS3 free base
  • 1009104-85-1
  • Specific Inhibitor of Smad3, SIS3