Atorvastatin Related Compound A

Product Name: Atorvastatin Related Compound A
CAS No.: 433289-83-9
Chemical Name: Atorvastatin Related Compound A
Synonyms: USP Impurity A;Adrafinil Impurity 4;Atorvastatin calcium-1;Atorvastatin Impurity A;DESFLUORO IMPURITY(IMP-A);Atorvastatin EP IMpurity A;Defluoro atorvastatin calcium;ATORVASTATIN DESFLUORO IMPURITY;Atorvastatin Related CoMpound A;Atorvastatin Calcium Impurity A
CBNumber: CB22521022
Molecular Formula: C33H35CaN2O5+
Formula Weight: 579.7194
MOL File: 433289-83-9.mol

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Atorvastatin Related Compound A Property

Melting point:: 150℃ (decomposition)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
Stability:: Hygroscopic
Major Application: pharmaceutical small molecule
InChIKey: HBFCHKRJRYFUBH-QXFSHCJSNA-M
SMILES: c1(-c2ccccc2)c(C(=O)Nc2ccccc2)c(C(C)C)[n](CC[C@@H](O)C[C@@H](O)CC([O-])=O)c1-c1ccccc1.[Ca+2] |&1:24,27,r|

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: WGK 2
HS Code: 2933997500
Storage Class: 11 - Combustible Solids
Hazard Classifications: Aquatic Chronic 2
STOT RE 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3858
Product name: Atorvastatin Related Compound A
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 30MG
Price: $614
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1044527
Product name: Atorvastatin Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $1200
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR1868
Product name: Atorvastatin Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 30mg
Price: $597
Updated: 2022/05/15

TRC

Product number: D289875
Product name: DefluoroAtorvastatinCalciumSalt
Packaging: 100mg
Price: $375
Updated: 2021/12/16

TRC

Product number: D289875
Product name: DefluoroAtorvastatinCalciumSalt
Packaging: 5mg
Price: $90
Updated: 2021/12/16

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Atorvastatin Related Compound A Chemical Properties,Usage,Production

Uses

Desfluoro Atorvastatin is an impurity in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Synthesis

Transfer [R,(R*,R*)]-2-(4-fluorophenyl)-??,??-dihydroxy-5-(1-methylethyl)-3-phenyl-[(anilino)-hydroxy]-1H-pyrrole-1-heptanoic acid sodium salt solution into 10L clean and dry kettle, and then add 3L of methanol into the kettle, and raise the temperature to 60 ??-65 ??, and slowly add calcium acetate solution by dripping slowly through the constant-pressure dropping funnel (Calcium acetate The solution was prepared by mixing 150g of calcium acetate monohydrate with 700ml of purified water and 700ml of methanol). At the end of the addition, keep warm and stir at 60??-65?? for 2 hours. Stopped heating, cooled to 5 ?? -10 ??, holding and stirring for 1 hour. Extract and filter to get white filter cake, which is the crude atorvastatin calcium. The atorvastatin calcium condensate was dissolved with mobile phase and loaded on a chromatographic column, and then separated by mobile phase elution, the eluate was collected in segments, the eluate containing defluorinated atorvastatin calcium was concentrated to dryness under reduced pressure, the concentrate was dissolved by adding ethyl acetate and washed with saturated citric acid, and the organic phase was concentrated to dryness under reduced pressure to obtain a white foamy solid with a purity of 99.6%, after plasma-park detection MS(ESI). [M+H]+:855, which is defluorinated atorvastatin calcium.

Atorvastatin Related Compound A Preparation Products And Raw materials

Raw materials

Preparation Products

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Atorvastatin Related Compound A Suppliers

Canada 1 China 69 India 16 United Kingdom 2 United States 7 Global 95

Guangzhou Juntang Technology Co., Ltd

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J & K SCIENTIFIC LTD.

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Email: jkinfo@jkchemical.com
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Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
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S.Z. PhyStandard Bio-Tech. Co., Ltd.

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Wuxi Zhongkun Biochemical Technology Co., Ltd.

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Shanghai Kewel Chemical Co., Ltd.

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BOC Sciences

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Tonichem Pharmaceutical Technology Co., Ltd.

Tel: +86 (0752) 222-7171, +86 15815821171
Fax: +86 (0752) 222-6171
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Beijing Solarbio Science & Tecnology Co., Ltd.

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Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
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ProdList: 131957
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View Lastest Price from Atorvastatin Related Compound A manufacturers

Career Henan Chemical Co

Product: Calcium bis{(3R,5R)-3,5-dihydroxy-7-[2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl]heptanoate} 433289-83-9
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-02

433289-83-9, Atorvastatin Related Compound ARelated Search:

Atorvastatin IMpurity 8 (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Atorvastatin IMpurity 3 Atorvastatin Acetonide N,3-Diphenyl-2-(2-methyl-1-oxopropyl)4-oxo-N-benzenebutanamide (Mixture of Diastereomers) Atorvastatin Impurity 16 3S, 5S enantioMer of Atorvastatin CalciuM Atorvastatin Impurity 22 Atorvastatin IMpurity 6 Dihydroxy Diketo Atorvastatin IMpurity O-Methyl Atorvastatin Calcium Salt Atorvastatin Impurity 10 Atorvastatin Lactum Calcium Salt Impurity Difluoro Atorvastatin Acetonide tert-Butyl Ester 2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide 2,3-Dehydroxy Atorvastatin Sodium Salt Atorvastatin Dehydro Lactone Atorvastatin Impurity 20

Atorvastatin EP IMpurity A

Desfluoro Atorvastatin Calcium Salt

(betaR,deltaR)-beta,delta-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1)

Atorvastatin Impurity A

(βR,δR)-β,δ-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt

Calcium (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)h

ATORVASTATIN DESFLUORO IMPURITY

Atorvastatin USP Related Compound A

Atorvastatin Calcium Hydrate impurity 22

(3R,5R)-3,5-dihydroxy-7-(2-isopropyl-

Atorvastatin calcium-1

Atorvastatin Related Compound A (20 mg) (Desfluoro impurity, or (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl-4,5- diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt)

Atorvastatin Related CoMpound A

Desfluoro iMpurity, or (3R,5R)-7-[3-(phenylcarbaMoyl)-2-isopropyl-4,5-diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt

Desfluoro Atorvastatin SodiuM Salt

calciuM (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbaMoyl)-1H-pyrrol-1-yl)heptanoate

USP Impurity A

(βR,δR)-β,δ-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Calcium Salt (2:1)

((3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3- (phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate) calcium(II)

Calcium bis{(3R,5R)-3,5-dihydroxy-7-[2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl]heptanoate}

Atorvastatin impurity 4/Atorvastatin EP Impurity A Calcium Salt/Defluoro Atorvastatin Calcium Salt/(3R,5R)-3,5-Dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate, calcium salt (2:1)

Atorvastatin Calcium Impurity A

Atorvastatin EP ImpurityABCDEFGHJKL

USP Atorvastatin Related Compound A

"Defluoridated atorvastatin calcium" Atorvastatin calcium 2020 Pharmacopoeia impurity I)“

Defluorocarbon atorvastatin calcium

Atorvastatin EP Impurity AQ: What is Atorvastatin EP Impurity A Q: What is the CAS Number of Atorvastatin EP Impurity A Q: What is the storage condition of Atorvastatin EP Impurity A Q: What are the applications of Atorvastatin EP Impurity A

Atorvastatin Related Compound A (Desfluoro impurity, or (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl- (1044527)

Atorvastatin Impurity 26 Calcium Salt (Atorvastatin EP Impurity A Calcium Salt)

(3R,5R)-3,5-Dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoic acid, calcium salt (Atorvastatin Impurity)

(3R,5R)-3,5-Dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate, calcium salt (2:1)

DESFLUORO IMPURITY(IMP-A)

(βR,δR)-β,δ-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Calcium Salt

(3R,5R)-7-[3-(Phenylcarbamoyl)-2-isopropyl-4,5- diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt

(3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate

Adrafinil Impurity 4

Defluoro atorvastatin calcium

Atorvastatin Impurity 26 Calcium Salt

433289-83-9

C66H70CaN4O10

CaC33H36N2O52

C33H35N2O52Ca

111936