6-bromo-2-methylimidazo[1,2-a]pyrimidine
- Product Name
- 6-bromo-2-methylimidazo[1,2-a]pyrimidine
- CAS No.
- 1111638-05-1
- Chemical Name
- 6-bromo-2-methylimidazo[1,2-a]pyrimidine
- Synonyms
- 6-bromo-2-methylimidazo[1,2-a]pyrimidine;6-fluoro-2-methylimidazo[1,2-a]pyrimidine;IMidazo[1,2-a]pyriMidine, 6-broMo-2-Methyl-;6-Bromo-2-methylimidazo[1,2-a]pyrimidine 97%
- CBNumber
- CB22522458
- Molecular Formula
- C7H6BrN3
- Formula Weight
- 212.05
- MOL File
- 1111638-05-1.mol
6-bromo-2-methylimidazo[1,2-a]pyrimidine Property
- Density
- 1.76±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.81±0.30(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 3H32-9-C8
- Product name
- 6-Bromo-2-methylimidazo[1,2-a]pyrimidine
- Packaging
- 250mg
- Price
- $239
- Updated
- 2021/12/16
- Product number
- NUC0000899
- Product name
- 6-BROMO-2-METHYLIMIDAZO[1,2-A]PYRIMIDINE
- Purity
- 95.00%
- Packaging
- 0.25G
- Price
- $380
- Updated
- 2021/12/16
- Product number
- 145041
- Product name
- 6-Bromo-2-methylimidazo[1,2-a]pyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $417
- Updated
- 2021/12/16
- Product number
- 2000AQ
- Product name
- 6-bromo-2-methylimidazo[1,2-a]pyrimidine
- Packaging
- 250mg
- Price
- $420.8
- Updated
- 2021/12/16
- Product number
- OR350418
- Product name
- 6-Bromo-2-methylimidazo[1,2-a]pyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $505
- Updated
- 2021/12/16
6-bromo-2-methylimidazo[1,2-a]pyrimidine Chemical Properties,Usage,Production
Synthesis
7752-82-1
78-95-5
1111638-05-1
Example B-8: Preparation of (2S)-1-(4-(1-isopropyl-3-(2-methylimidazo[1,2-a]pyrimidin-6-yl)-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ol (B-8). Preparation of 6-bromo-2-methylimidazo[1,2-a]pyrimidine (B-8-2). To a mixed solution of 5-bromopyrimidin-2-amine (170.0 g, 0.98 mol) in isopropanol (2 L) and N,N-dimethylformamide (500 mL) was added 1-chloro-2-propanone (606 g, 6.53 mol). The reaction mixture was stirred at 100 °C for 16 hours. Completion of the reaction was confirmed by monitoring the progress of the reaction by thin layer chromatography (TLC) (unfolding agent ratio: petroleum ether/ethyl acetate = 1:2). After completion of the reaction, the reaction was quenched with sodium carbonate (Na2CO3) solution and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (eluent ratio: petroleum ether/ethyl acetate=5:1) to afford the target compound B-8-2 (10.0 g, 4.8% yield) as a yellow solid.
References
[1] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 75-76
6-bromo-2-methylimidazo[1,2-a]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
6-bromo-2-methylimidazo[1,2-a]pyrimidine Suppliers
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- +86-21-68182121
- Fax
- +86-21-68182121
- Country
- China
- ProdList
- 882
- Advantage
- 52
- Tel
- 021-20958197 20965099
- Fax
- 021-20960837
- sales@skychemical.com
- Country
- China
- ProdList
- 1183
- Advantage
- 57
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 15332490153
- Fax
- QQ 2725398181
- newprochem@126.com
- Country
- China
- ProdList
- 991
- Advantage
- 55
- Tel
- 021-58957915 17721108391
- Fax
- QQ: 907522080
- 907522080@qq.com
- Country
- China
- ProdList
- 996
- Advantage
- 55
- Tel
- 021-20960837,QQ1332204249
- Fax
- 021-20960837
- sales@skychemical.com
- Country
- China
- ProdList
- 3341
- Advantage
- 55
- Tel
- 0510-86010668
- Fax
- 0510-86010668
- sales@biopharmamatrix.com
- Country
- China
- ProdList
- 4739
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-66113011 13155353615
- Fax
- (7)02557626880
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15394
- Advantage
- 58