5-Bromo-2-cyclopropylpyrimidine
- Product Name
- 5-Bromo-2-cyclopropylpyrimidine
- CAS No.
- 304902-96-3
- Chemical Name
- 5-Bromo-2-cyclopropylpyrimidine
- Synonyms
- 5-Bromo-2-cyclopropylpyrimidine;2-Cyclopropyl-5-bromopyrimidine;Pyrimidine, 5-bromo-2-cyclopropyl-;5-bromo-2-cyclopropylpyrimidine-4,6-d2;5-Bromo-2-cyclopropylpyrimidine - [B15587];5-Bromo-2-cyclopropylpyrimidine ISO 9001：2015 REACH
- CBNumber
- CB22525752
- Molecular Formula
- C7H7BrN2
- Formula Weight
- 199.05
- MOL File
- 304902-96-3.mol
5-Bromo-2-cyclopropylpyrimidine Property
- Boiling point:
- 255℃
- Density
- 1.657
- Flash point:
- 108℃
- storage temp.
- Store at room temperature
- pka
- 0.67±0.22(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C7H7BrN2/c8-6-3-9-7(10-4-6)5-1-2-5/h3-5H,1-2H2
- InChIKey
- ANURJXNEVQWODA-UHFFFAOYSA-N
- SMILES
- C1(C2CC2)=NC=C(Br)C=N1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B750510
- Product name
- 5-Bromo-2-cyclopropylpyrimidine
- Packaging
- 1g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 3H32-9-CA
- Product name
- 5-Bromo-2-cyclopropylpyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- HCH0366836
- Product name
- 5-BROMO-2-CYCLOPROPYLPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $267.75
- Updated
- 2021/12/16
- Product number
- X2004
- Product name
- 5-Bromo-2-cyclopropylpyrimidine
- Packaging
- 25g
- Price
- $2211
- Updated
- 2021/12/16
- Product number
- 124829
- Product name
- 5-Bromo-2-cyclopropylpyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $594
- Updated
- 2021/12/16
5-Bromo-2-cyclopropylpyrimidine Chemical Properties,Usage,Production
Uses
5-Bromo-2-cyclopropylpyrimidine is a reagent used in the synthesis of novel glucocorticoid modulators which are used in the treatment of inflammatory diseases.
Synthesis
23719-80-4
183438-24-6
304902-96-3
5-Bromo-2-iodopyrimidine (5.00 g, 17.6 mmol) and tetrakis(triphenylphosphine)palladium(0) (5.70 mg, 5.00 mmol) were dissolved in tetrahydrofuran (80 mL). Cyclopropylmagnesium bromide (0.5 mol/L in THF, 70.0 mL, 35.0 mmol) was added slowly and dropwise under nitrogen protection. The reaction mixture was stirred at 70 °C for 2 hours. After completion of the reaction, the reaction solution was diluted with water (20 mL) and subsequently extracted with ethyl acetate (50 mL x 3). The organic phases were combined and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 50:1) to afford 5-bromo-2-cyclopropylpyrimidine (1.20 g, 35% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.51 (s, 2H), 2.17-2.11 (m, 1H), 1.04-1.02 (m, 4H). Mass spectrum (ESI) showed m/z 199 ([M + H]+).
References
[1] Patent: US2015/51395, 2015, A1. Location in patent: Paragraph 1352-1353
5-Bromo-2-cyclopropylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2-cyclopropylpyrimidine manufacturers
- Product
- 5-Bromo-2-cyclopropyl-pyrimidine 304902-96-3
- Price
- US $3.90-5.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-12
- Product
- 5-Bromo-2-cyclopropylpyrimidine 304902-96-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-02
- Product
- 5-bromo-2-cyclopropylpyrimidine 304902-96-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10