3-Bromo-2,4-difluoronitrobenzene 98%
- Product Name
- 3-Bromo-2,4-difluoronitrobenzene 98%
- CAS No.
- 103977-78-2
- Chemical Name
- 3-Bromo-2,4-difluoronitrobenzene 98%
- Synonyms
- 1-Bromo-2,6-difluoro-3-nitrobenzene;3-Bromo-2,4-difluoronitrobenzene98%;3-Bromo-2,4-difluoronitrobenzene 98%;Benzene, 2-bromo-1,3-difluoro-4-nitro-;3-bromo-9-(tetrahydro-2H-pyran-2-yl)-9H-carbazole
- CBNumber
- CB22527079
- Molecular Formula
- C6H2BrF2NO2
- Formula Weight
- 237.99
- MOL File
- 103977-78-2.mol
3-Bromo-2,4-difluoronitrobenzene 98% Property
- Boiling point:
- 254.0±35.0 °C(Predicted)
- Density
- 1.890±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- crystalline solid
- color
- Pale lemon
- InChI
- InChI=1S/C6H2BrF2NO2/c7-5-3(8)1-2-4(6(5)9)10(11)12/h1-2H
- InChIKey
- IQCPYFIIMNLQNU-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=C([N+]([O-])=O)C(F)=C1Br
Safety
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B690298
- Product name
- 2-Bromo-1,3-difluoro-4-nitrobenzene
- Packaging
- 500mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- PC49157
- Product name
- 3-Bromo-2,4-difluoronitrobenzene
- Purity
- 98%
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- 4654-B-05
- Product name
- 3-Bromo-2,4-difluoronitrobenzene
- Purity
- 98%
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- 1592AJ
- Product name
- 2-Bromo-1,3-difluoro-4-nitrobenzene
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- PC49157
- Product name
- 3-Bromo-2,4-difluoronitrobenzene
- Purity
- 98%
- Packaging
- 5g
- Price
- $243
- Updated
- 2021/12/16
3-Bromo-2,4-difluoronitrobenzene 98% Chemical Properties,Usage,Production
Synthesis
64248-56-2
103977-78-2
The general procedure for the synthesis of 2-bromo-1,3-difluoro-4-nitrobenzene from 1-bromo-2,6-difluorobenzene was as follows: 2,6-difluorobromobenzene (125.5 g, 650 mmol) was dissolved in 98% sulfuric acid (250 mL) and the mixture was cooled in an ice-water bath. Subsequently, nitration reagent (100 mL) consisting of a 1:1 mixture of 98% sulfuric acid and fuming nitric acid was slowly added dropwise, and the rate of dropwise acceleration was controlled to ensure that the internal temperature of the reaction system did not exceed 35°C. The reaction was carried out in a controlled manner. After titration, the reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was slowly poured into ice water and diluted with water to a final volume of 5 L. The precipitated solid product was collected by filtration, washed well with water, and then dried under vacuum in the presence of phosphorus pentoxide to afford a cream-colored solid of 2-bromo-1,3-difluoro-4-nitrobenzene (145 g, 94% yield). The product was characterized by 1H NMR (360 MHz, CDCl3): δ 7.15 (1H, m), 8.09-8.16 (1H, m).
References
[1] Patent: US4623650, 1986, A
[2] Patent: WO2003/93272, 2003, A1. Location in patent: Page/Page column 38
[3] Tetrahedron Letters, 2010, vol. 51, # 4, p. 600 - 601
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5927 - 5932
[5] Patent: CN108117553, 2018, A. Location in patent: Paragraph 0105; 0106; 0119-0121
3-Bromo-2,4-difluoronitrobenzene 98% Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-2,4-difluoronitrobenzene 98% manufacturers
- Product
- 3-Bromo-2,4-difluoronitrobenzene 103977-78-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 200kg
- Release date
- 2020-02-01