Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate
- Product Name
- Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate
- CAS No.
- 1174046-84-4
- Chemical Name
- Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate
- Synonyms
- Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3;ethyl 4-ethoxy-2-oxo-1H-pyridine-3-carboxylate;Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxyla;thyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate;Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate;3-Pyridinecarboxylic acid, 4-ethoxy-1,2-dihydro-2-oxo-, ethyl ester;Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate ISO 9001：2015 REACH
- CBNumber
- CB22533933
- Molecular Formula
- C10H13NO4
- Formula Weight
- 211.21
- MOL File
- 1174046-84-4.mol
Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate Property
- Boiling point:
- 424.6±45.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.29±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 449255
- Product name
- Ethyl 4-ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate
- Packaging
- 25mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- E900078
- Product name
- Ethyl4-ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 6774AJ
- Product name
- Ethyl4-ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate
- Packaging
- 1g
- Price
- $258
- Updated
- 2021/12/16
- Product number
- CD11341155
- Product name
- Ethyl4-ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CD11341155
- Product name
- Ethyl4-ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $198
- Updated
- 2021/12/16
Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate Chemical Properties,Usage,Production
Synthesis
1345855-03-9
1174046-84-4
General procedure for the synthesis of ethyl 2-oxo-4-ethoxy-1,2-dihydropyridine-3-carboxylate from ethyl 2-cyano-5-(dimethylamino)-3-ethoxypenta-2,4-dienoate: ethyl 2-cyano-5-(dimethylamino)-3-ethoxypenta-2,4-dienoate (15.0 g, 63 mmol) was mixed with acetic acid (600 mL) and reacted at reflux overnight. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove the solvent. The residue was treated with water and washed with ethyl acetate (2×). The aqueous layer was adjusted to pH 9-10 with sodium bicarbonate and extracted with dichloromethane (3×). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Finally, it was purified by silica gel column chromatography to afford ethyl 2-oxo-4-ethoxy-1,2-dihydropyridine-3-carboxylate (9.0 g, 67% yield).
References
[1] Patent: WO2014/145004, 2014, A1. Location in patent: Paragraph 0103
[2] Patent: WO2011/139891, 2011, A1. Location in patent: Page/Page column 59
[3] Patent: WO2013/78295, 2013, A2. Location in patent: Paragraph 00184
Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate manufacturers
- Product
- Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate 1174046-84-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-21
- Product
- Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate 1174046-84-4
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg; 10kg; 25kg
- Release date
- 2020-01-07