Droxinostat
- Product Name
- Droxinostat
- CAS No.
- 99873-43-5
- Chemical Name
- Droxinostat
- Synonyms
- CS-425;NS 41080;Droxinostat;Droxinostat (NS41080);Droxinostat NS41080 NS-41080;4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide;4-(4-Chloro-2-methyl-phenoxy)-N-hydroxy-butyramide;ButanaMide, 4-(4-chloro-2-Methylphenoxy)-N-hydroxy-;HDAC3,hepatocellular carcinoma (HCC),Droxinostat,NS-41080,Apoptosis,Histone deacetylases,cancer,inhibit,HDAC6,HDAC8,Inhibitor,histone deacetylase (HDAC),HDAC,NS41080
- CBNumber
- CB22537542
- Molecular Formula
- C11H14ClNO3
- Formula Weight
- 243.69
- MOL File
- 99873-43-5.mol
Droxinostat Property
- Density
- 1.252
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- color
- white to off-white
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 23869
- Product name
- Droxinostat
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 23869
- Product name
- Droxinostat
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 23869
- Product name
- Droxinostat
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 23869
- Product name
- Droxinostat
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $317
- Updated
- 2024/03/01
- Product number
- D689890
- Product name
- Droxinostat
- Packaging
- 10mg
- Price
- $115
- Updated
- 2021/12/16
Droxinostat Chemical Properties,Usage,Production
Uses
Droxinostat is a histone deacetylase selective inhibitor and is used in cancer therapy and cancer research. Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8.
Definition
ChEBI: 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide is an aromatic ether.
Biological Activity
droxinostat is a selective inhibitor of hdac3, hdac6, and hdac8 with ic50 value of 16.9 ± 5.0 μm, 2.47 ± 1.09 μm, and 1.46 ± 0.11 μm, respectively [1].hdacs (histone deacetylases) are enzymes responsible of the deacetylation of lysine that residues of core histones and play a pivotal role in controlling chromatin remodeling and transcriptional activation. it is also reported that hdacs control the acetylation and activation status of multiple non-histone proteins, including the heat shock protein 90 (hsp90) which is an essential molecular chaperone for fungal virulence and antifungal resistance. multiple hdacs have been identified and hdac1 to hdac10 are shown to express in malignant cells which reminds the hdac inhibitor as a target for cancer therapy [2] [3].droxinostat is a selective hdac inhibitor and is different from the known pan-hdaci tsa which inhibits all tested hdac. when tested with prostate cancer line ppc-1 cells, droxinostat treatment selectively inhibited hdac3, hdac6, and hdac8 activity at the concentration of 50 μm/l which sensitized cells to death ligands [1]. in androgen-dependent cap cells, administration of droxinostat selectively inhibited hdacs and downregulated c-flp expression which resulted in cells apoptosis [4].
target
HDAC8
References
[1]. wood, t.e., et al., selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. mol cancer ther, 2010. 9(1): p. 246-56.
[2]. lamoth, f., p.r. juvvadi, and w.j. steinbach, histone deacetylase inhibition as an alternative strategy against invasive aspergillosis. front microbiol, 2015. 6: p. 96.
[3]. mackmull, m.t., et al., histone deacetylase inhibitors cause the selective depletion of bromodomain containing proteins. mol cell proteomics, 2015.
[4]. mccourt, c., et al., elevation of c-flip in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy. clin cancer res, 2012. 18(14): p. 3822-33.
Droxinostat Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Droxinostat manufacturers
- Product
- Droxinostat 99873-43-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25