HMN-214

Product Name: HMN-214
CAS No.: 173529-46-9
Chemical Name: HMN-214
Synonyms: CS-25;HMN-214;IVX-214|||HMN214;HMN-214 USP/EP/BP;HMN-214;HMN214;HMN 214;HMN-214 IVX-214 HMN214;HMN-214;HMN214;HMN 214;IVX214;IVX-214; HMN214; HMN 214; IVX 214; IVX-214; IVX214;(E)-4-(2-(N-((4-methoxyphenyl)sulfonyl)acetamido)styryl)pyridine 1-oxide;4-[(1E)-2-{2-[N-(4-methoxybenzenesulfonyl)acetamido]phenyl}ethenyl]pyridin-1-ium-1-olate
CBNumber: CB22537582
Molecular Formula: C22H20N2O5S
Formula Weight: 424.47
MOL File: 173529-46-9.mol

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HMN-214 Property

Boiling point:: 663.1±65.0 °C(Predicted)
Density: 1.24
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: ≥21.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 0.86±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26210
Product name: HMN-214
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 26210
Product name: HMN-214
Packaging: 25mg
Price: $365
Updated: 2024/03/01

Cayman Chemical

Product number: 26210
Product name: HMN-214
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 26210
Product name: HMN-214
Packaging: 10mg
Price: $169
Updated: 2024/03/01

TRC

Product number: H456360
Product name: HMN214
Packaging: 5mg
Price: $100
Updated: 2021/12/16

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HMN-214 Chemical Properties,Usage,Production

Description

HMN-214 is an orally bioavailable prodrug form of HMN-176, an indirect inhibitor of polo-like kinase (PLK) activity that inhibits proliferation of a variety of cancer cells. HMN-214 decreases the expression of multidrug resistance gene 1 (MDR1) in AB-A.1 cells and in tumors isolated from mice bearing multidrug-resistant KB-A1 xenografts. HMN-214 (20 mg/kg per day) reduces tumor volume in PC3, WiDr, and A549 mouse xenograft models. It does not decrease nerve conduction velocity or compound action potential amplitude in rabbit sciatic nerves in vivo when administered at a concentration of 30 mg/kg per day.

Uses

HMN 214 is a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. It is a prodrug of HMN 176, a stilbene derivative that interferes with the subcellular spatial location of polo-like kinase-1 (PLK1).

Definition

ChEBI: N-(4-methoxyphenyl)sulfonyl-N-[2-[2-(1-oxido-4-pyridin-1-iumyl)ethenyl]phenyl]acetamide is a sulfonamide.

in vitro

hmn-176 showed potent cytotoxicity, with a mean ic50 of 118 nm. the cytotoxic effecacy of hnm-176 was superior to that of adm, vp-16 and cddp, but inferior to that of taxol and vcr. hmn-176 showed less vaiance in log(ic50) than did the reference agents. in addition, judging by its low resistance indices, hmn-176 was more cytotoxic toward the drug-resistant phenotypes of tumor cells than were the other agents tested [1].

in vivo

pk studies showed that hnm-214 was an acceptable oral prodrug of hmn-176. in the in vivo analysis of the schedule-dependency of hmn-214, the repeated administration for over 5 days elicited potent antitumor activity, as expected from the exposure-dependency of the cytotoxicity of hmn-176 and from the cytometric studies. the antitumor activity of hmn-214 against human tumor xenografts was equal or superior to that of clinically avaiable agents, including cis-platinum, adriamycin, vincristine and uft without severe toxicity such as neurotoxicity [1].

target

PLK1

IC 50

hmn-176 showed potent cytotoxic activity against several tumor cell lines with an average ic50 of 118 nmol/l

References

[1] takagi m, honmura t, watanabe s, yamaguchi r, nogawa m, nishimura i, katoh f, matsuda m, hidaka h. in vivo antitumor activity of a novel sulfonamide, hmn-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, hmn-176. invest new drugs. 2003 nov;21(4):387-99.
[2] garland ll, taylor c, pilkington dl, cohen jl, von hoff dd. a phase i pharmacokinetic study of hmn-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. clin cancer res. 2006 sep 1;12(17):5182-9.

HMN-214 Preparation Products And Raw materials

Raw materials

Preparation Products

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HMN-214 Suppliers

China 94 France 1 India 1 Japan 1 United Kingdom 1 United States 16 Global 114

AdooQ BioScience, LLC

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Target molecule Corp.

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Cckinase, Inc.

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BOC Sciences

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173529-46-9, HMN-214Related Search:

BAY 11-7082 AZD9496 MS436 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine GSK461364 Dasatinib Avagacestat (BMS-708163) (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-

HMN-214

(E)-4-[2-[2-[N-Acetyl-N-[(4-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine 1-oxide

HMN-214;HMN214;HMN 214

Acetamide, N-[(4-methoxyphenyl)sulfonyl]-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-

(E)-4-[2-[2-[N-Acetyl-N-[(4-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine 1-oxide HMN 214

HMN-214;HMN214;HMN 214;IVX214

CS-25

(E)-4-(2-(N-((4-methoxyphenyl)sulfonyl)acetamido)styryl)pyridine 1-oxide

IVX-214; HMN214; HMN 214; IVX 214; IVX-214; IVX214

HMN-214 USP/EP/BP

4-[(1E)-2-{2-[N-(4-methoxybenzenesulfonyl)acetamido]phenyl}ethenyl]pyridin-1-ium-1-olate

HMN-214 IVX-214 HMN214

IVX-214|||HMN214

173529-46-9

Inhibitors