4-(HYDROXYMETHYL)PHENYLACETIC ACID
- Product Name
- 4-(HYDROXYMETHYL)PHENYLACETIC ACID
- CAS No.
- 73401-74-8
- Chemical Name
- 4-(HYDROXYMETHYL)PHENYLACETIC ACID
- Synonyms
- 2-(4-(hydroxyMethyl)phenyl)acetic acid;PAM LINKER;HO-PAM-LINKER;Loxoprofen Impurity 161;4-(Carboxymethyl)benzyl alcohol;4-(HYDROXYMETHYL)PHENYLACETIC ACID;p-(Hydroxymethyl)phenylacetic Acid;1-(4-Hydroxymethyl)phenylacetic acid;2-(4-(Hydroxymethyl)phenyl)aceticaci;4-(Hydroxymethyl)phenylacetic acid 98%
- CBNumber
- CB2254520
- Molecular Formula
- C9H10O3
- Formula Weight
- 166.17
- MOL File
- 73401-74-8.mol
4-(HYDROXYMETHYL)PHENYLACETIC ACID Property
- Melting point:
- 131-134 °C (lit.)
- Boiling point:
- 357.8±22.0 °C(Predicted)
- Density
- 1.271±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 4.27±0.10(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C9H10O3/c10-6-8-3-1-7(2-4-8)5-9(11)12/h1-4,10H,5-6H2,(H,11,12)
- InChIKey
- FWZBPBKAANKOJQ-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=C(CO)C=C1
- CAS DataBase Reference
- 73401-74-8(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- 579610
- Product name
- 4-(Hydroxymethyl)phenylacetic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $71.5
- Updated
- 2025/07/31
- Product number
- 579610
- Product name
- 4-(Hydroxymethyl)phenylacetic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $57.3
- Updated
- 2023/06/20
- Product number
- H1473
- Product name
- 4-(Hydroxymethyl)phenylacetic Acid
- Purity
- >97.0%(T)
- Packaging
- 1g
- Price
- $57
- Updated
- 2025/07/31
- Product number
- H1473
- Product name
- 4-(Hydroxymethyl)phenylacetic Acid
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $167
- Updated
- 2025/07/31
- Product number
- H972623
- Product name
- 4-(Hydroxymethyl)phenylacetic Acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
4-(HYDROXYMETHYL)PHENYLACETIC ACID Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
4-(Hydroxymethyl)phenylacetic acid can serve as the main body of insoluble polypeptide. 4-(Hydroxymethyl)phenylacetic acid contains a benzen ring with substituted 1, 4 position[1].
Synthesis
13737-36-5
73401-74-8
The general procedure for the synthesis of 4-(hydroxymethyl)benzeneacetic acid from 4-bromomethylphenylacetic acid was as follows: 4-bromomethylphenylacetic acid (2.3 kg, 10.0 mol, 1 eq.) was added to an aqueous (90 L) solution of sodium hydroxide (1.61 kg, 40.2 mol, 4 eq.) and the resulting mixture was stirred at room temperature overnight. After confirming the complete consumption of 4-bromomethylphenylacetic acid by TLC analysis, the reaction mixture was carefully acidified with concentrated sulfuric acid (1.0 L) to a pH of about 2. Subsequently, solid sodium chloride (25 kg) was added to the mixture, followed by extraction with ethyl acetate (33 L × 3). The combined organic phases were washed with brine, dried over anhydrous sodium sulfate, and concentrated until a significant amount of solid precipitated. The resulting suspension was kept at 4-6 °C overnight to promote further crystallization. The solid product was collected by filtration and the filter cake was washed with petroleum ether (2 L × 2) to afford 4-(hydroxymethyl)benzeneacetic acid (1.2 kg, yield: 71.9%). HPLC purity was 97.8% (220 nm); 1H NMR (300 MHz, DMSO-d6) δ 12.27 (s, 1H), 7.26-7.12 (m, 4H), 5.14 ( s, 1H), 4.47 (s, 2H), 3.53 (s, 2H).
References
[1] Zhou Bin, et al. Coupled peptide chain for dissolving insoluble polypeptide and its application in liquid phase chromatography separation and purification. China, CN105001307 A. 2015-10-28.
4-(HYDROXYMETHYL)PHENYLACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(HYDROXYMETHYL)PHENYLACETIC ACID manufacturers
- Product
- 4-(HYDROXYMETHYL)PHENYLACETIC ACID 73401-74-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-22
- Product
- 4-(Hydroxymethyl)phenylacetic acid 73401-74-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 4-(Hydroxymethyl)phenylacetic acid 73401-74-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08