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Silybin

Product Name
Silybin
CAS No.
802918-57-6
Chemical Name
Silybin
Synonyms
Silybin A,B (Mixture);Silybin (Mixture of Diastereomers);(2R,3R)-3,5,7-Trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one;4H-1-Benzopyran-4-one, 2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
CBNumber
CB22545743
Molecular Formula
C25H22O10
Formula Weight
482.44
MOL File
802918-57-6.mol
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Silybin Property

Melting point:
152-153°C
Boiling point:
793.0±60.0 °C(Predicted)
Density 
1.527±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Acetone (Sparingly, Sonicated, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
pka
7.39±0.60(Predicted)
form 
Solid
color 
Pale Yellow to Beige
InChIKey
SEBFKMXJBCUCAI-DBMPWETRSA-N
SMILES
[C@H]1(C2=CC=C3OC(CO)C(C4=CC=C(O)C(OC)=C4)OC3=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
RTECS 
DJ2981770
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89280
Product name
Silybin (A + B mixture)
Purity
phyproof? Reference Substance
Packaging
25mg
Price
$286
Updated
2024/03/01
Sigma-Aldrich
Product number
02000585
Product name
Silybin
Purity
mixture of Silybin A and B, primary reference standard
Packaging
25mg
Price
$845
Updated
2024/03/01
TRC
Product number
S465850
Product name
Silybin (A + B mixture)
Packaging
5g
Price
$120
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
53021
Product name
Silybin (A + B mixture)
Packaging
100mg
Price
$610
Updated
2021/12/16
AvaChem
Product number
3619
Product name
Silybin
Packaging
1g
Price
$129
Updated
2021/12/16
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Silybin Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

Reference standard in the analysis of herbal medicinal products.

Uses

Hepatoprotectant. In nature, the flavonolignan Silybin occurs as a mixture of two diastereomers, Silybin A and Silybin B.

General Description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

in vivo

Silybin (50, 100?mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation[2].

Animal Model:Male C57BL/6J mice (6-8 weeks old) with nonalcoholic fatty liver disease (NAFLD)[2]
Dosage:50, 100?mg/kg
Administration:Given intragastrically; daily; for the last 4 weeks
Result:Significantly lowered both serum and hepatic lipid accumulation.

Silybin Preparation Products And Raw materials

Raw materials

Preparation Products

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Silybin Suppliers

Canada 1 China 46 India 2 United States 3 Global 52
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Hubei kangen Pharmaceutical Chemical Co., Ltd
Tel
153-15337215803 15337215803
Fax
027-89771658
Email
3357312443@qq.com
Country
China
ProdList
662
Advantage
56
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-85370565-229 18080489829
Email
3004654993@qq.com
Country
China
ProdList
8914
Advantage
60
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
021-58958618
Email
sales@uhnshanghai.com
Country
China
ProdList
1942
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Wuhan ChemNorm Biotech Co.,Ltd.
Tel
+86-27-8439 4403 18971486879
Fax
+86-27-8439 4403
Email
sales@chemnorm.com
Country
CHINA
ProdList
2935
Advantage
58

802918-57-6, SilybinRelated Search:


  • Silybin A,B (Mixture)
  • Silybin (Mixture of Diastereomers)
  • 4H-1-Benzopyran-4-one, 2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
  • (2R,3R)-3,5,7-Trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one
  • 802918-57-6
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Pharmaceuticals