ChemicalBook > CAS DataBase List > 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

Product Name
1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile
CAS No.
350797-56-7
Chemical Name
1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile
Synonyms
SL-5;Silodosin Nitro Impurity;3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate;1-(3-Benzoyloxypropyl)-7-cyano-5-(2-nitropropyl) indoline.;1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-in...;3-[7-cyano-5-(2-nitropropyl)-2,3-dihydroindol-1-yl]propyl benzoate;3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate (Silodosin Impurity);1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile;1H-Indole-7-carbonitrile, 1-[3-(benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-
CBNumber
CB22546472
Molecular Formula
C22H23N3O4
Formula Weight
393.44
MOL File
350797-56-7.mol
More
Less

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Property

Melting point:
73-75°C
Boiling point:
608.6±55.0 °C(Predicted)
Density 
1.27
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
7.80±0.13(Predicted)
form 
Solid
color 
Light Yellow to Yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
C982035
Product name
3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propylBenzoate
Packaging
5g
Price
$135
Updated
2021/12/16
AK Scientific
Product number
J11149
Product name
SilodosinImpurity9
Packaging
25mg
Price
$95
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0129703
Product name
1-[3-(BENZOYLOXY)PROPYL]-2,3-DIHYDRO-5-(2-NITROPROPYL)-1H-INDOLE-7-CARBONITRILE
Purity
95.00%
Packaging
5MG
Price
$499.76
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0129703
Product name
1-[3-(BENZOYLOXY)PROPYL]-2,3-DIHYDRO-5-(2-NITROPROPYL)-1H-INDOLE-7-CARBONITRILE
Purity
95.00%
Packaging
25G
Price
$1000
Updated
2021/12/16
Ambeed
Product number
A350878
Product name
3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propylbenzoate
Purity
97+%
Packaging
250mg
Price
$5
Updated
2021/12/16
More
Less

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Chemical Properties,Usage,Production

Uses

3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl Benzoate is used in the preparation of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.

Synthesis

350797-55-6

350797-56-7

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde (20.0 g) was used as a starting material and dissolved in tetrahydrofuran (29.0 ml). To this solution, hydroxylamine hydrochloride (4.21 g) and pyridine (16.0 ml) were added sequentially. The reaction mixture was stirred at a constant temperature at 50 °C for 2 h. Acetic anhydride (9.0 ml) was subsequently added. Stirring of the reaction mixture was continued at 80°C for 2 hours. After completion of the reaction, extraction was carried out with toluene. The toluene layer obtained by extraction was washed with dilute hydrochloric acid, after which the solvent was removed by distillation under reduced pressure to give 16.0 g of propyl 3-(7-cyano-5-(2-nitropropyl)dihydroindol-1-yl)benzoate (Compound XX).

References

[1] Patent: WO2011/124704, 2011, A1. Location in patent: Page/Page column 19-20
[2] Patent: WO2013/56842, 2013, A1. Location in patent: Page/Page column 19
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 8, p. 3826 - 3839

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Suppliers

China 99 India 4 United States 1 Global 104
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2805
Advantage
65
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
Advantage
52
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Lihe Wuhan New Chemical Materials Co., Ltd.
Tel
027-88395709
Fax
027-88391805
Country
China
ProdList
429
Advantage
50
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5674
Advantage
50
Intelligence Pharm Science(Shanghai) Co., Ltd.
Tel
021-57898186
Fax
021-37699262
Country
China
ProdList
449
Advantage
55
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
2267
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1991
Advantage
55
Hubei Yangxin Medical Technology Co., Ltd.
Tel
15374522761
Fax
QQ:2853117752
Email
3003392093@yongstandards.com
Country
China
ProdList
10000
Advantage
55
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Aikon International Limited
Tel
025-58859352 18068836627
Fax
(5)02557626880
Email
dt3@aikonchem.com
Country
China
ProdList
15493
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Shanghai Time Chemicals CO., Ltd.
Tel
021-57951555
Fax
021-57951555
Email
tianshihuagong1111@163.com
Country
CHINA
ProdList
1356
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Aishilun biotechnology (Shanghai) co., LTD
Tel
021-50676523 18019098996
Email
info@acelybio.com
Country
China
ProdList
3960
Advantage
58
Hebei Chuanghai Biotechnology Co,.LTD
Tel
+86-13131129325
Fax
86-0311-66562153
Email
sales1@chuanghaibio.com
Country
China
ProdList
5249
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
sgtlifesciences pvt ltd
Tel
+8617013299288
Email
dj@sgtlifesciences.com
Country
China
ProdList
12373
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Baoji Guokang Healthchem co.,ltd
Tel
+8615604608665 15604608665
Email
dominicguo@gk-bio.com
Country
CHINA
ProdList
9414
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15109
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23912
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Jinan Finer Chemical Co., Ltd
Tel
+86-531-88989536 +86-15508631887
Fax
+86-531-88989539
Email
sales@finerchem.com
Country
China
ProdList
2952
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
Beijing xinyanhui pharmaceutical research and development co., LTD
Tel
13969155946
Email
1461866103@qq.com
Country
China
ProdList
16111
Advantage
58
Wuhan Ying Yuan Bei Biological Limited
Tel
13349903920 13349903920;
Email
1540154086@qq.com
Country
China
ProdList
3004
Advantage
58
Jinan blalong chemical co. LTD
Tel
2710913286@.com
Email
1513643261@qq.com
Country
China
ProdList
14246
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-021-13773155751 19975051755
Email
260924549@qq.com
Country
China
ProdList
10524
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-81148696 +86-17392712697
Email
1022@dideu.com
Country
China
ProdList
3995
Advantage
58
Beijing Haite lesk Technology Co., Ltd
Tel
15210893940; 15116916250
Fax
QQ: 237008221
Email
chemistryliu@163.com
Country
China
ProdList
7327
Advantage
58
Changzhou Kechem Bio-Scientific Co., LTD.
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26028
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
Email
sales@mitachieve.com
Country
China
ProdList
8860
Advantage
58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd
Tel
1701086315
Fax
1701086315@qq.com
Email
dexuanpharma@126.com
Country
China
ProdList
9475
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7986
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Taian Ruijia Xu Chemical Industry Tech Co Ltd
Tel
15552805326
Email
vsk1967@outlook.com
Country
China
ProdList
341
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81124267 17392282731
Fax
029-88380327
Email
1073@dideu.com
Country
China
ProdList
9992
Advantage
58
Chemsigma International Co., Ltd.
Tel
025-58748998 18951874644
Email
elsa.cheng@chemsigma.com
Country
China
ProdList
1598
Advantage
58
Foshan Treasure Biotechnology Co., Ltd
Tel
0757-85921206 18520245316
Email
2329783215@qq.com
Country
China
ProdList
12661
Advantage
58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
Email
2881924765@qq.com
Country
China
ProdList
7938
Advantage
58
More
Less

View Lastest Price from 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile 350797-56-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10000KGS
Release date
2025-02-18
Hebei Chuanghai Biotechnology Co,.LTD
Product
Silodosin 350797-56-7
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-21
Shaanxi Dideu Medichem Co. Ltd
Product
1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile 350797-56-7
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000Tons
Release date
2024-08-04

350797-56-7, 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrileRelated Search:

Silodosin Impurity 18 Silodosin β-D-Glucuronide N-Carboxybenzyl O-Methyl Tri-acetate Silodosin Impurity 26 NCFJJNFEEPMRAQ-XMMPIXPASA-N Silodosin 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate Silodosin 1H-Indole-7-carbonitrile, 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]- O-Acetyl Silodosin 1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]-1H-indole-7-carboxaMide Silodosin Carboxylic Acid Impurity (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-1-(3-hydroxypropyl)indoline-7-carboxamide(WXG00186) Silodosin β-D-Glucuronide Sodium Salt Silodosin Glucuronide Silodosin-d4 (Chiral) 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile Silodosin Impurity 33 Silodosin-d6

  • 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate
  • SL-5
  • 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile
  • 3-[7-cyano-5-(2-nitropropyl)-2,3-dihydroindol-1-yl]propyl benzoate
  • Silodosin Nitro Impurity
  • 1H-Indole-7-carbonitrile, 1-[3-(benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-
  • 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-in...
  • 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate (Silodosin Impurity)
  • 1-(3-Benzoyloxypropyl)-7-cyano-5-(2-nitropropyl) indoline.
  • 350797-56-7