2'-Azido-2'-deoxy-5-methyluridine

Product Name: 2'-Azido-2'-deoxy-5-methyluridine
CAS No.: 97748-75-9
Chemical Name: 2'-Azido-2'-deoxy-5-methyluridine
Synonyms: 2’-Azido-2’-deoxy-5-methyluridine;2'-Azido-2'-deoxy-5-methyluridine;Uridine, 2′-azido-2′-deoxy-5-methyl-;1-(2'-azido-2'-deoxy-β-β-D-ribofuranosyl)thymine;1-[3-AZIDO-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE
CBNumber: CB22546528
Molecular Formula: C10H13N5O5
Formula Weight: 283.24
MOL File: 97748-75-9.mol

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Hazard and Precautionary Statements (GHS)

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2'-Azido-2'-deoxy-5-methyluridine Chemical Properties,Usage,Production

Uses

2′-Azido-2′-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2′-Azido-2′-deoxy-5-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

2'-Azido-2'-deoxy-5-methyluridine Preparation Products And Raw materials

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97748-75-9, 2'-Azido-2'-deoxy-5-methyluridineRelated Search:

Uridine

1-[3-AZIDO-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE

1-(2'-azido-2'-deoxy-β-β-D-ribofuranosyl)thymine

2'-Azido-2'-deoxy-5-methyluridine

2’-Azido-2’-deoxy-5-methyluridine

Uridine, 2′-azido-2′-deoxy-5-methyl-

97748-75-9