N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide

Product Name: N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
CAS No.: 1190378-57-4
Chemical Name: N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
Synonyms: CS-2840;MRT68921;MRT67307;MRT67307 HCl;MRT67307 (free base);MRT67307 hydrochloride;MRT67307 HCl(free-base);IKKε/TBK1 Inhibitor II, MRT67307 - CAS 1190378-57-4 - Calbiochem;N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide;Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-
CBNumber: CB22547040
Molecular Formula: C26H36N6O2
Formula Weight: 464.6
MOL File: 1190378-57-4.mol

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N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Property

Density: 1.270
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: H2O: soluble15mg/mL, clear
form: powder
pka: 15.94±0.20(Predicted)
color: white to light brown
InChIKey: UKBGBACORPRCGG-UHFFFAOYSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0702
Product name: MRT67307 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0702
Product name: MRT67307 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $543
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.06306
Product name: IKKε/TBK1 Inhibitor II, MRT67307 - CAS 1190378-57-4 - Calbiochem
Packaging: 5mg
Price: $209
Updated: 2024/03/01

Cayman Chemical

Product number: 19916
Product name: MRT67307
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19916
Product name: MRT67307
Purity: ≥95%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

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N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Chemical Properties,Usage,Production

Uses

MRT67307 hydrochloride has been used to study its effect on LPS (lipopolysaccharide) -induced lysosome tubulation.

Definition

ChEBI: N-[3-[[5-cyclopropyl-2-[3-(4-morpholinylmethyl)anilino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide is an aromatic amine.

Biochem/physiol Actions

MRT67307 is an amino-pyrimidine derivative and has an IC50 value of 19. It is known to induce TLR (toll like receptor) mediated anti inflammatory cytokine generation. Also, MRT67307 prevents the secretion of cytokines associated with proinflammation.

target

IKKe

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Suppliers

China 73 United States 16 Global 89

Musechem

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1190378-57-4, N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamideRelated Search:

MRT67307

MRT67307 hydrochloride

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide hydrochloride

MRT68921

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide

MRT67307 (free base)

IKKε/TBK1 Inhibitor II, MRT67307 - CAS 1190378-57-4 - Calbiochem

MRT67307 HCl

CS-2840

Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-

MRT67307 HCl(free-base)

1190378-57-4

C26H36N6O2xHCl

API

NF-kB