(1-Phenyl-4-piperidyl)Methanol
- Product Name
- (1-Phenyl-4-piperidyl)Methanol
- CAS No.
- 697306-45-9
- Chemical Name
- (1-Phenyl-4-piperidyl)Methanol
- Synonyms
- (1-Phenylpiperidin-4-yl);1-Phenyl-4-piperidinemethanol;(1-Phenyl-4-piperidyl)Methanol;4-Piperidinemethanol, 1-phenyl-;(1-Phenyl-4-piperidinyl)methanol
- CBNumber
- CB22548340
- Molecular Formula
- C12H17NO
- Formula Weight
- 191.27
- MOL File
- 697306-45-9.mol
(1-Phenyl-4-piperidyl)Methanol Property
- Boiling point:
- 327.2±15.0 °C(Predicted)
- Density
- 1.061
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.94±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P400383
- Product name
- (1-Phenylpiperidin-4-yl)methanol
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 084259
- Product name
- (1-Phenylpiperidin-4-yl)methanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $488
- Updated
- 2021/12/16
- Product number
- OR952959
- Product name
- (1-Phenylpiperidin-4-yl)methanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $573
- Updated
- 2021/12/16
- Product number
- CHM0066316
- Product name
- (1-PHENYLPIPERIDIN-4-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1018.71
- Updated
- 2021/12/16
- Product number
- CHM0066316
- Product name
- (1-PHENYLPIPERIDIN-4-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2643.8
- Updated
- 2021/12/16
(1-Phenyl-4-piperidyl)Methanol Chemical Properties,Usage,Production
Synthesis
247022-37-3
697306-45-9
General procedure for the synthesis of (1-phenyl-4-piperidinyl)methanol from ethyl 1-phenylpiperidine-4-carboxylate: To a solution of ethyl 1-phenylpiperidine-4-carboxylate (2.6 g, 6.86 mmol) in tetrahydrofuran (THF, 32 mL) was slowly added lithium aluminum hydride (325 mg, 8.58 mmol) at 0 °C. The reaction mixture was kept stirred at 0 °C for 2 hours. Upon completion of the reaction, the reaction was quenched by careful addition of saturated aqueous ammonium chloride solution and the insoluble material was removed by decantation. The organic layer was separated and dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=4/1) to afford (1-phenyl-4-piperidinyl)methanol (1.3 g, 99% yield) as a colorless solid.1H NMR (400 MHz, CDCl3) δ (ppm): 1.25-1.46 (m, 3H), 1.62-1.69 (m, 1H), 1.83- 1.88 (m, 2H), 2.72 (td, J=12.2,2.4Hz, 1H), 3.55 (t, J=5.8Hz, 2H), 3.69-3.74 (m, 2H), 6.81-6.96 (m, 3H), 7.23-7.28 (m, 2H).
References
[1] Patent: WO2004/46107, 2004, A1. Location in patent: Page 227
(1-Phenyl-4-piperidyl)Methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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