2-Chloro-5-(trifluoroMethoxy)pyridine
- Product Name
- 2-Chloro-5-(trifluoroMethoxy)pyridine
- CAS No.
- 1206972-45-3
- Chemical Name
- 2-Chloro-5-(trifluoroMethoxy)pyridine
- Synonyms
- 2-Chloro-5-(trifluoromethoxy);2-Chloro-5-(trifluoroMethoxy)pyridine;Pyridine, 2-chloro-5-(trifluoromethoxy)-;2-Chloro-5-(trifluoromethoxy)pyridine 97%
- CBNumber
- CB22550327
- Molecular Formula
- C6H3ClF3NO
- Formula Weight
- 197.54
- MOL File
- 1206972-45-3.mol
2-Chloro-5-(trifluoroMethoxy)pyridine Property
- Boiling point:
- 41-43 °C(Press: 15 Torr)
- Density
- 1.463±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.55±0.10(Predicted)
- form
- liquid
- color
- Colourless
- InChI
- InChI=1S/C6H3ClF3NO/c7-5-2-1-4(3-11-5)12-6(8,9)10/h1-3H
- InChIKey
- PONLSAHALFQCNY-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(OC(F)(F)F)C=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C382718
- Product name
- 2-Chloro-5-(trifluoromethoxy)pyridine
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 101346
- Product name
- 2-Chloro-5-(trifluoromethoxy)pyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- 101346
- Product name
- 2-Chloro-5-(trifluoromethoxy)pyridine
- Purity
- 97%
- Packaging
- 500mg
- Price
- $113
- Updated
- 2021/12/16
- Product number
- 101346
- Product name
- 2-Chloro-5-(trifluoromethoxy)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $174
- Updated
- 2021/12/16
- Product number
- 3594AA
- Product name
- 2-Chloro-5-(trifluoromethoxy)pyridine
- Packaging
- 500mg
- Price
- $202
- Updated
- 2021/12/16
2-Chloro-5-(trifluoroMethoxy)pyridine Chemical Properties,Usage,Production
Synthesis
1221171-73-8
1206972-45-3
General procedure for the synthesis of 2-chloro-5-(trifluoromethoxy)pyridine (6) from 2-chloro-5-trichloromethoxypyridine (5,7.4 g, 30.0 mmol): 2-chloro-5-trichloromethoxypyridine (5) was added slowly and dropwise to a molten mixture of SbF3 (10.7 g, 60.0 mmol, 2.0 equiv) and SbCl5 (1.4 g, 0.6 mL, 4.6 mmol, 0.15 equiv) in a molten mixture. The reaction mixture was stirred at 120 °C to 150 °C for 3 h. The progress of the reaction was monitored by gas chromatography (GC) to confirm the complete conversion of the feedstock and the disappearance of the by-product OCF2Cl. Upon completion of the reaction, the mixture was cooled to 0 °C and dissolved in dichloromethane (100 mL). Subsequently, the reaction was quenched with saturated aqueous sodium bicarbonate solution (100 mL) and potassium fluoride solution (20%, 50 mL), and the aqueous layer was extracted with dichloromethane (2 x 50 mL). The organic layers were combined, dried with anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The crude product was purified by vacuum distillation to give 2-chloro-5-(trifluoromethoxy)pyridine (6,3.6 g, 18.0 mmol, 60% yield) as a colorless oil. The boiling point of the product was 41-43 °C/20 mbar.1H NMR (CDCl3, 300 MHz): δ=8.35 (s,1H), 7.55 (d,J=8.7Hz,1H), 7.41 (d,J=8.7Hz,1H).13C NMR (CDCl3, 75 MHz): δ=149.3,142.7,140.1, 131.3,125.1,120.2 (q,J=259Hz).MS (EI): m/z=197[M+],162[M+-Cl].
References
[1] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 19-20
[2] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066
[3] Patent: US2015/307465, 2015, A1. Location in patent: Paragraph 0630
2-Chloro-5-(trifluoroMethoxy)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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