3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester
- Product Name
- 3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester
- CAS No.
- 79128-68-0
- Chemical Name
- 3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester
- Synonyms
- methyl 3-[(trifluoroacetyl)amino]thiophene-2-carboxylate;Methyl 3-(2,2,2-trifluoroacetaMido)thiophene-2-carboxylate;3-(N-TrifluoroacetylaMino)thiophene-2-carboxylic acid Methyl ester;3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester;3-(N-Trifluoroacetylamino)thiophene-2-carboxylic acid methyl ester, 97.5%;2-Thiophenecarboxylic acid, 3-[(2,2,2-trifluoroacetyl)amino]-, methyl ester
- CBNumber
- CB22550448
- Molecular Formula
- C8H6F3NO3S
- Formula Weight
- 253.2
- MOL File
- 79128-68-0.mol
3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester Property
- storage temp.
- 2-8°C(protect from light)
- Appearance
- Light yellow to yellow Solid
Safety
- Safety Statements
- 24/25
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0030396
- Product name
- Methyl3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylate
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- CS-0030396
- Product name
- Methyl3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylate
- Purity
- >97.0%
- Packaging
- 5g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CS-0030396
- Product name
- Methyl3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylate
- Purity
- >97.0%
- Packaging
- 10g
- Price
- $141
- Updated
- 2021/12/16
- Product number
- 090763
- Product name
- Methyl 3-(2,2,2-trifluoroacetamido)-thiophene-2-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $364
- Updated
- 2021/12/16
- Product number
- HCH0369223
- Product name
- METHYL-3-(2,2,2-TRIFLUOROACETAMIDO)THIOPHENE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.19
- Updated
- 2021/12/16
3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester Chemical Properties,Usage,Production
Synthesis
22288-78-4
407-25-0
79128-68-0
To a stirred solution of methyl 3-amino-2-thiophenecarboxylate (25.0 g, 159 mmol) in acetonitrile (325 mL) was added sequentially pyridine (15.5 mL) and trifluoroacetic anhydride (29.3 mL) at 0 °C. After 5 minutes of reaction, the reaction mixture was slowly warmed to room temperature and stirring was continued for 20 minutes. Subsequently, the reaction mixture was slowly poured into ice water (3.0 L) and stirred for 15 minutes to quench the reaction. The resulting precipitate was collected by filtration, washed with cold water and dried under vacuum to afford methyl 3-(2,2,2-trifluoroacetamido)-2-thiophenecarboxylate (37.3 g, 93% yield) as a pink solid. Its 1H NMR (300 MHz, DMSO-d6) data were as follows: δ 3.86 (3H, s), 7.72 (1H, d, J = 5.4 Hz), 8.03 (1H, d, J = 5.4 Hz), 11.17 (1H, br s).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2535 - 2539
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 13, p. 6293 - 6302
[3] Patent: WO2010/101302, 2010, A1. Location in patent: Page/Page column 129-130
[4] Patent: WO2005/47293, 2005, A1. Location in patent: Page/Page column 28
[5] Patent: WO2007/71434, 2007, A1. Location in patent: Page/Page column 27
3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester manufacturers
- Product
- 3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester 79128-68-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester 79128-68-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester 79128-68-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02