ChemicalBook > CAS DataBase List > A 887826

A 887826

Product Name
A 887826
CAS No.
1266212-81-0
Chemical Name
A 887826
Synonyms
A 887826;A887826,A 887826;5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-Morpholinyl)-3-pyridinyl]Methyl]-3-pyridinecarboxaMide;3-Pyridinecarboxamide, 5-(4-butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl]-
CBNumber
CB22550796
Molecular Formula
C26H29ClN4O3
Formula Weight
480.99
MOL File
1266212-81-0.mol
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A 887826 Property

Boiling point:
711.5±60.0 °C(Predicted)
Density 
1.230±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥5mg/mL
pka
8.85±0.46(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0345
Product name
A 887826
Purity
≥98% (HPLC)
Packaging
5mg
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0345
Product name
A 887826
Purity
≥98% (HPLC)
Packaging
25mg
Price
$523
Updated
2024/03/01
Tocris
Product number
4249
Product name
A 887826
Purity
≥97%(HPLC)
Packaging
10
Price
$221
Updated
2021/12/16
Tocris
Product number
4249
Product name
A 887826
Purity
≥97%(HPLC)
Packaging
50
Price
$868
Updated
2021/12/16
TRC
Product number
A101250
Product name
A 887826
Packaging
10mg
Price
$145
Updated
2021/12/16
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A 887826 Chemical Properties,Usage,Production

Uses

A structurally novel, potent and voltage-dependent Nav1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

Biological Activity

a 887826 is a potent and voltage-dependent nav1.8 sodium channel blocker. it blocked recombinant human nav1.8 channels with an ic50 value of 11nm [1].voltage-gated sodium channels are important in the generation and propagation of action potential. at least 9 genes encode functional sodium channels, namely nav1.1-nav1.9. nav1.8 is a ttx-resistant (ttx-r) sodium channel. nav1.8 is highly localized on primary sensory afferent neurons. nav1.8 is involved in the processing of nociceptive information.-100 mv without prepulse did make a resting state for rat drg neurons. prepulse to -40 mv did make an inactivated state for channels. in rat drg neurons in these two states, treatment with a 887826 at 1 μm significantly blocked ttxr na+ currents. a 887826 blocked ttx-r na+ currents with an ic50 value of 7.9 ± 0.2 nm (n= 5~9) when channels were in an inactivated state (-40 mv). a 887826 showed an ic50 value of 63.6 ± 0.2 nm (n=5~9) to less depolarized (at -60, -80 or -100 mv) ttx-r na+ currents. that meant a 887826 state-dependently blocked ttx-r na+ currents [1].knockdown of nav1.8 caused a significant reduction in mechanical hyperalgesia and allodynia in rat models of inflammatory and neuropathic pain. suppression of nav1.8 expression also reduced visceral pain in several experimental models. activation of nav1.8 sodium channels primarily drove nociceptor excitability under cold conditions. a rat spinal nerve ligation model of neuropathic pain was used. oral administration with a 887826 dose-dependently attenuated tactile allodynia in this pain model. the range of free plasma concentrations of a 887826 to produce analgesic efficacy in a spinal nerve ligation model was 3-10 nm. this was consistent with the ic50 value for blocking rat drg ttx-r sodium currents [1].

storage

Store at RT

References

[1]. zhang xf, shieh cc, chapman ml, et al. a-887826 is a structurally novel, potent and voltage-dependent nav1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. neuropharmacology, 2010, 59(3): 201-207.

A 887826 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 887826 Suppliers

EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
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8447
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
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32161
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United States Biological
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sales@advtechind.com
Country
United States
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6075
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ApexBio Technology
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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Riedel-de Haen AG
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Country
United States
ProdList
6773
Advantage
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1266212-81-0, A 887826Related Search:


  • A 887826
  • 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-Morpholinyl)-3-pyridinyl]Methyl]-3-pyridinecarboxaMide
  • 3-Pyridinecarboxamide, 5-(4-butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl]-
  • A887826,A 887826
  • 1266212-81-0
  • Aromatics, Heterocycles, Neurochemicals, Pharmaceuticals, Intermediates & Fine Chemicals
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Neurochemicals
  • Pharmaceuticals