benzyl 2,4-difluorophenylcarbaMate

Product Name: benzyl 2,4-difluorophenylcarbaMate
CAS No.: 112434-18-1
Chemical Name: benzyl 2,4-difluorophenylcarbaMate
Synonyms: benzyl 2,4-difluorophenylcarbaMate;(2,4-Difluorophenyl)carbamic acid benzyl ester;Carbamic acid, N-(2,4-difluorophenyl)-, phenylmethyl ester
CBNumber: CB22552745
Molecular Formula: C14H11F2NO2
Formula Weight: 263.24
MOL File: 112434-18-1.mol

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benzyl 2,4-difluorophenylcarbaMate Property

Boiling point:: 312.1±42.0 °C(Predicted)
Density: 1.329±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 11.69±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0368557
Product name: BENZYL-(2,4-DIFLUOROPHENYL)CARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $502.55
Updated: 2021/12/16

Matrix Scientific

Product number: 071203
Product name: Benzyl 2,4-difluorophenylcarbamate
Purity: 97%
Packaging: 5g
Price: $615
Updated: 2021/12/16

AK Scientific

Product number: 2182AA
Product name: Benzyl(2,4-difluorophenyl)carbamate
Packaging: 5g
Price: $1546
Updated: 2021/12/16

Chemenu

Product number: CM128599
Product name: benzyl(2,4-difluorophenyl)carbamate
Purity: 95+%
Packaging: 5g
Price: $1036
Updated: 2021/12/16

Crysdot

Product number: CD12179772
Product name: Benzyl(2,4-difluorophenyl)carbamate
Purity: 97%
Packaging: 5g
Price: $1097
Updated: 2021/12/16

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benzyl 2,4-difluorophenylcarbaMate Chemical Properties,Usage,Production

Synthesis

367-25-9

501-53-1

112434-18-1

To a 250 mL round bottom flask was added 2,4-difluoroaniline (11.4 g, 4.62 mL, 45.4 mmol), dichloromethane (DCM, 103 mL) and pyridine (7.40 mL, 91 mmol). The reaction mixture was stirred at room temperature and benzyl chloroformate (8.15 mL, 54.5 mmol) was slowly added dropwise through the addition funnel. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature overnight. Upon completion of the reaction, the mixture was poured into water and extracted with DCM. The organic phases were combined, washed sequentially with water and saturated saline, and then dried over anhydrous sodium sulfate. After filtration to remove the desiccant, the filtrate was concentrated under reduced pressure to afford benzyl (2,4-difluorophenyl)-carbamate (11.1 g, 42.2 mmol, 93% yield) as a white solid, which could be used for subsequent reactions without further purification.LC-MS (ESI, positive ion mode) analysis: calculated value of C14H11F2NO2 [M+H]+: 263.1; Measured value: 263.1. measured value [M+Na]+: 286.1. 1H NMR (400 MHz, DMSO-d6) δ ppm: 9.43 (br s, 1H), 7.51-7.66 (m, 1H), 7.24-7.46 (m, 6H), 7.01-7.12 (m, 1H), 5.15 (s, 2H).

References

[1] Tetrahedron Letters, 2006, vol. 47, # 36, p. 6393 - 6396
[2] Canadian Journal of Chemistry, 2009, vol. 87, # 2, p. 393 - 396
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 10, p. 2215 - 2234
[4] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2607 - 2610
[5] Patent: US2008/167338, 2008, A1. Location in patent: Page/Page column 44-45

benzyl 2,4-difluorophenylcarbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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benzyl 2,4-difluorophenylcarbaMate Suppliers

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112434-18-1, benzyl 2,4-difluorophenylcarbaMateRelated Search:

benzyl 2,4-difluorophenylcarbaMate

(2,4-Difluorophenyl)carbamic acid benzyl ester

Carbamic acid, N-(2,4-difluorophenyl)-, phenylmethyl ester

112434-18-1