ChemicalBook > CAS DataBase List > 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester

3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester

Product Name
3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester
CAS No.
442903-28-8
Chemical Name
3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester
Synonyms
Methyl 2,4-dichloropyridine-3-carboxylate;2,4-dichloro-, Methyl ester;4-dichloropyridine-3-carboxylate;Methyl 2,4-dichloronicotinic acid;2,4-Dichloro nicotinic acid Methyl ester;2,4-Dichloro-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester;Methyl 2,4-dichloropyridine-3-carboxylate, 2,4-Dichloro-3-(methoxycarbonyl)pyridine
CBNumber
CB22554082
Molecular Formula
C7H5Cl2NO2
Formula Weight
206.03
MOL File
442903-28-8.mol
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3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester Property

Boiling point:
266.2±35.0 °C(Predicted)
Density 
1.426±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.24±0.10(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C7H5Cl2NO2/c1-12-7(11)5-4(8)2-3-10-6(5)9/h2-3H,1H3
InChIKey
IBZIEMCFERTPNR-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(Cl)=C1C(OC)=O
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
M301400
Product name
Methyl2,4-dichloronicotinate
Packaging
250mg
Price
$75
Updated
2021/12/16
TRC
Product number
M301400
Product name
Methyl2,4-dichloronicotinate
Packaging
500mg
Price
$115
Updated
2021/12/16
Apolloscientific
Product number
OR46030
Product name
Methyl2,4-dichloronicotinate
Packaging
250mg
Price
$145
Updated
2021/12/16
Matrix Scientific
Product number
047150
Product name
Methyl 2,4-dichloronicotinate
Purity
>95%
Packaging
1g
Price
$603
Updated
2021/12/16
AK Scientific
Product number
W6318
Product name
methyl2,4-dichloronicotinate
Packaging
10g
Price
$717
Updated
2021/12/16
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3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester Chemical Properties,Usage,Production

Synthesis

262423-77-8

74-88-4

442903-28-8

GENERAL STEPS: 2,4-Dichloronicotinic acid (500 mg, 2.60 mmol) was dissolved in acetonitrile (10 mL) and cooled to 0°C. Subsequently, DBU (0.981 mL, 6.51 mmol) and iodomethane (0.814 mL, 13.0 mmol) were sequentially added to the solution. The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (10 mL), washed once with water (5 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate-hexane) to afford methyl 2,4-dichloronicotinate (260 mg, 1.262 mmol, 49% yield) as a light yellow oil.LC/MS (ESI) m/z 206.1 [(M + H)+, calculated value of 205.97 for C7H6Cl2NO2]; LC/MS retention time ( Method D): tR = 0.85 min. 1H NMR (300 MHz, CD3OD) δ ppm 8.42 (d, J = 5.4 Hz, 1H), 7.59 (d, J = 5.4 Hz, 1H), 3.99 (s, 3H).

References

[1] Tetrahedron Letters, 2011, vol. 52, # 4, p. 523 - 525
[2] Patent: WO2015/116060, 2015, A1. Location in patent: Page/Page column 92
[3] Patent: JP2015/528018, 2015, A. Location in patent: Paragraph 0190
[4] Patent: WO2017/218960, 2017, A1. Location in patent: Paragraph 00607

3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester manufacturers

Career Henan Chemical Co
Product
3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester 442903-28-8
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-14

442903-28-8, 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl esterRelated Search:


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  • 2,4-Dichloro nicotinic acid Methyl ester
  • Methyl 2,4-dichloropyridine-3-carboxylate
  • Methyl 2,4-dichloropyridine-3-carboxylate, 2,4-Dichloro-3-(methoxycarbonyl)pyridine
  • 2,4-dichloro-, Methyl ester
  • 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester
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  • Methyl 2,4-dichloronicotinic acid
  • 442903-28-8