6-Chloro-4-methoxypyridine-3-carbonitrile
- Product Name
- 6-Chloro-4-methoxypyridine-3-carbonitrile
- CAS No.
- 1187190-69-7
- Chemical Name
- 6-Chloro-4-methoxypyridine-3-carbonitrile
- Synonyms
- 6-chloro-4-Methoxynicotinonitrile;6-Chloro-4-methoxypyridine-3-carbonitrile;6-Chloro-4-methoxy-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-chloro-4-methoxy-;6-Chloro-4-Methoxy-Nicotinonitrile(WX683504);6-Chloro-4-Methoxy-Nicotinonitrile Achiral 73.43
- CBNumber
- CB22556460
- Molecular Formula
- C7H5ClN2O
- Formula Weight
- 168.58
- MOL File
- 1187190-69-7.mol
6-Chloro-4-methoxypyridine-3-carbonitrile Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- C369758
- Product name
- 6-Chloro-4-methoxynicotinonitrile
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C369758
- Product name
- 6-Chloro-4-methoxynicotinonitrile
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- HCH0367955
- Product name
- 6-CHLORO-4-METHOXYNICOTINONITRILE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $246.75
- Updated
- 2021/12/16
- Product number
- 066788
- Product name
- 6-Chloro-4-methoxypyridine-3-carbonitrile
- Purity
- >95%
- Packaging
- 500mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- OR303813
- Product name
- 6-Chloro-4-methoxynicotinonitrile
- Packaging
- 500mg
- Price
- $351
- Updated
- 2021/12/16
6-Chloro-4-methoxypyridine-3-carbonitrile Chemical Properties,Usage,Production
Synthesis
166526-03-0
124-41-4
1187190-69-7
Synthesis of 6-chloro-4-methoxy-3-cyanopyridine (2): to a solution of 4,6-dichloronicotinonitrile (1) (200 mg, 1.06 mmol) in anhydrous methanol (10 mL) was added sodium methanol solution (0.5 M in MeOH, 2.12 mL, 1.06 mmol). The reaction mixture was stirred at 60 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and neutralized by addition of hydrochloric acid (1 M, 8 mL). Subsequently, the volatile components were removed by distillation under reduced pressure. The product was purified by a Biotage fast chromatography system (elution gradient: 10%-50% ethyl acetate/hexane) to afford 6-chloro-4-methoxy-3-cyanopyridine (150 mg, 77% yield). The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 8.48 (s, 1H), 6.98 (s, 1H), 4.03 (s, 3H).
References
[1] Patent: US2015/291629, 2015, A1. Location in patent: Paragraph 1104
6-Chloro-4-methoxypyridine-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
6-Chloro-4-methoxypyridine-3-carbonitrile Suppliers
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 13761627472
- Fax
- 86-21-64965863
- 183009664@qq.com
- Country
- China
- ProdList
- 649
- Advantage
- 62
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3992
- Advantage
- 55
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 0512-0512-52358471 17715136450
- Fax
- 05125235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 12127
- Advantage
- 58
- Tel
- 0371-56787280 13137706083
- Fax
- -
- m18539565376@163.com
- Country
- China
- ProdList
- 970
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60