2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin

Product Name: 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
CAS No.: 599150-20-6
Chemical Name: 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
Synonyms: HPI 1;GLI antagonist-1;Hedgehog Pathway Inhibitor 1;Hh Signaling Antagonist XII, HPI-1;HPI-1, hedgehog signaling inhibitor;Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroqui;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquino;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin;4-(3-Hydroxyphenyl)-1-(2-methoxyethyl)-7-(2-methoxyphenyl)-2-methyl-4,6,7,8-tetrahydroquinolin-5(1H)-one
CBNumber: CB22557144
Molecular Formula: C27H29NO6
Formula Weight: 463.52
MOL File: 599150-20-6.mol

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2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Property

Boiling point:: 638.2±55.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
pka: 9.67±0.10(Predicted)
form: Pale yellow solid
color: Light yellow to yellow

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 2
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H1542
Product name: HPI-1 hydrate
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: 373275
Product name: Hh Signaling Antagonist XII, HPI-1
Packaging: 10mg
Price: $280
Updated: 2023/01/07

Cayman Chemical

Product number: 15221
Product name: HPI-1
Purity: ≥95%
Packaging: 10mg
Price: $142
Updated: 2021/12/16

Cayman Chemical

Product number: 15221
Product name: HPI-1
Purity: ≥95%
Packaging: 5mg
Price: $79
Updated: 2021/12/16

Sigma-Aldrich

Product number: H1542
Product name: HPI-1 hydrate
Packaging: 25mg
Price: $530
Updated: 2024/03/01

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2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Chemical Properties,Usage,Production

Uses

HPI-1 is a Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor.

General Description

A cell-permeable oxo-tetrahydroquinolinecarboxylate compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu^+/+ NIH 3T3 (shh-LIGHT2) and Sufu^-/- fibroblast cultures (IC₅₀ = 1.5 & 3 μM, respectively) in a manner similar to two other Hh downstream blockers, HPI-3 (Cat. No. 373276) and GANT-61 (Cat. No. 373401). However, only HPI-1, but not HPI-3 or GANT-61 (no effect at 30 μM), remains effective against Sufu^-/- fibroblasts overexpressing Gli1 or Gli2 (IC₅₀ = 6 & 4 μM, respectively). HPI-1 is also shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing primary murine CGNPs (Cerebellar Granule Neuron Precursors) and NIH 3T3 (smoM2-LIGHT) cultures.

Biological Activity

hedgehog (hh) signaling inhibitor. inhibits sonic hedgehog (shh)-, sag- and gli-induced hh pathway activation in shh-light2 cells (ic50 values are 1.5, 1.5, 4 and 6 μm for shh-, sag-, gli2- and gli1-induced activation). also inhibits hh pathway activation

storage

Store at -20°C

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Suppliers

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599150-20-6, 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolinRelated Search:

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4-(3-Hydroxyphenyl)-1-(2-methoxyethyl)-7-(2-methoxyphenyl)-2-methyl-4,6,7,8-tetrahydroquinolin-5(1H)-one

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Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem

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599150-20-6