ChemicalBook > CAS DataBase List > 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin

Product Name
2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
CAS No.
599150-20-6
Chemical Name
2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
Synonyms
HPI 1;GLI antagonist-1;HPI 1, 10 mM in DMSO;Hedgehog Pathway Inhibitor 1;Hh Signaling Antagonist XII, HPI-1;HPI-1, hedgehog signaling inhibitor;Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroqui;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquino;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
CBNumber
CB22557144
Molecular Formula
C27H29NO6
Formula Weight
463.52
MOL File
599150-20-6.mol
More
Less

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Property

Boiling point:
638.2±55.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO
pka
9.67±0.10(Predicted)
form 
Pale yellow solid
color 
Light yellow to yellow
More
Less

Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
HazardClass 
IRRITANT
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H1542
Product name
HPI-1 hydrate
Packaging
5mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
373275
Product name
Hh Signaling Antagonist XII, HPI-1
Packaging
10mg
Price
$280
Updated
2023/01/07
Cayman Chemical
Product number
15221
Product name
HPI-1
Purity
≥95%
Packaging
10mg
Price
$142
Updated
2021/12/16
Cayman Chemical
Product number
15221
Product name
HPI-1
Purity
≥95%
Packaging
5mg
Price
$79
Updated
2021/12/16
Sigma-Aldrich
Product number
H1542
Product name
HPI-1 hydrate
Packaging
25mg
Price
$530
Updated
2024/03/01
More
Less

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Chemical Properties,Usage,Production

Uses

HPI-1 is a Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor.

General Description

A cell-permeable oxo-tetrahydroquinolinecarboxylate compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu+/+ NIH 3T3 (shh-LIGHT2) and Sufu-/- fibroblast cultures (IC50 = 1.5 & 3 μM, respectively) in a manner similar to two other Hh downstream blockers, HPI-3 (Cat. No. 373276) and GANT-61 (Cat. No. 373401). However, only HPI-1, but not HPI-3 or GANT-61 (no effect at 30 μM), remains effective against Sufu-/- fibroblasts overexpressing Gli1 or Gli2 (IC50 = 6 & 4 μM, respectively). HPI-1 is also shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing primary murine CGNPs (Cerebellar Granule Neuron Precursors) and NIH 3T3 (smoM2-LIGHT) cultures.

Biological Activity

hedgehog (hh) signaling inhibitor. inhibits sonic hedgehog (shh)-, sag- and gli-induced hh pathway activation in shh-light2 cells (ic50 values are 1.5, 1.5, 4 and 6 μm for shh-, sag-, gli2- and gli1-induced activation). also inhibits hh pathway activation

storage

Store at -20°C

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin Suppliers

China 48 United Kingdom 1 United States 11 USA 1 Global 61
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

599150-20-6, 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolinRelated Search:


  • 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquino
  • 2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate
  • Hedgehog Pathway Inhibitor 1
  • HPI 1
  • 2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
  • 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroqui
  • Hh Signaling Antagonist XII, HPI-1
  • 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
  • 4-(3-Hydroxyphenyl)-1-(2-methoxyethyl)-7-(2-methoxyphenyl)-2-methyl-4,6,7,8-tetrahydroquinolin-5(1H)-one
  • 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester
  • Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem
  • SUM149,anti-proliferative,inhibit,colony formation,Gli,HPI 1,GLI1 mRNA,SUM159 cells,GLI antagonist1,GLI antagonist-1,Inhibitor,GLI antagonist 1
  • 3-Quinolinecarboxylic acid, 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-, 2-methoxyethyl ester
  • GLI antagonist-1
  • HPI-1, hedgehog signaling inhibitor
  • HPI 1, 10 mM in DMSO
  • 599150-20-6