Methyl 3-(tert-butoxycarbonylaMino)propanoate
- Product Name
- Methyl 3-(tert-butoxycarbonylaMino)propanoate
- CAS No.
- 42116-55-2
- Chemical Name
- Methyl 3-(tert-butoxycarbonylaMino)propanoate
- Synonyms
- Methyl 3-(Boc-amino)propanoate;Methyl 3-(tert-butoxycarbonylaMino)propanoate;methyl3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
- CBNumber
- CB22561332
- Molecular Formula
- C9H17NO4
- Formula Weight
- 203.24
- MOL File
- 42116-55-2.mol
Methyl 3-(tert-butoxycarbonylaMino)propanoate Property
- Boiling point:
- 292.4±23.0 °C(Predicted)
- Density
- 1.053±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 11.82±0.46(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M295338
- Product name
- methyl3-{[(tert-butoxy)carbonyl]amino}propanoate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- AAA0010834
- Product name
- METHYL-3-((TERT-BUTOXYCARBONYL)AMINO)PROPANOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.02
- Updated
- 2021/12/16
- Product number
- 5805AB
- Product name
- Methyl3-((tert-butoxycarbonyl)amino)propanoate
- Packaging
- 10g
- Price
- $744
- Updated
- 2021/12/16
- Product number
- AAA0010834
- Product name
- METHYL-3-((TERT-BUTOXYCARBONYL)AMINO)PROPANOATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $824
- Updated
- 2021/12/16
- Product number
- A155518
- Product name
- Methyl3-((tert-butoxycarbonyl)amino)propanoate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $896
- Updated
- 2021/12/16
Methyl 3-(tert-butoxycarbonylaMino)propanoate Chemical Properties,Usage,Production
Synthesis
24424-99-5
42116-55-2
General procedure for the synthesis of methyl 3-((tert-butoxycarbonyl)amino)propanoate from di-tert-butyl dicarbonate: β-alanine methyl ester hydrochloride (9.90 g, 70.93 mmol) was suspended in 200 mL of acetonitrile and triethylamine (10 mL, 72.14 mmol) was added. The reaction mixture was stirred at room temperature for 0.3 h. Subsequently, di-tert-butyl dicarbonate (15.48 g, 70.93 mmol) and zirconium(IV) chloride (1.65 g, 7.09 mmol) were added sequentially. The reaction mixture was continued to be stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporation. The residue was extracted with ethyl acetate and water, the organic phase was separated and dried over anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure to give the target product in a yield of 12.50 g with 87% yield.
References
[1] Patent: US2007/238730, 2007, A1. Location in patent: Page/Page column 22
[2] Patent: US2007/259855, 2007, A1. Location in patent: Page/Page column 24
[3] Organic Letters, 2006, vol. 8, # 14, p. 2993 - 2996
[4] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 13, p. 1607 - 1612
[5] Journal of Medicinal Chemistry, 1991, vol. 34, # 1, p. 73 - 78
Methyl 3-(tert-butoxycarbonylaMino)propanoate Preparation Products And Raw materials
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