ChemicalBook > CAS DataBase List > 3-broMo-5-fluoro-4-hydroxybenzaldehyde

3-broMo-5-fluoro-4-hydroxybenzaldehyde

Product Name: 3-broMo-5-fluoro-4-hydroxybenzaldehyde
CAS No.: 185345-46-4
Chemical Name: 3-broMo-5-fluoro-4-hydroxybenzaldehyde
Synonyms: 3-fluoro-4-hydroxy-5-bromobenzaldehyde;3-broMo-5-fluoro-4-hydroxybenzaldehyde;Benzaldehyde, 3-bromo-5-fluoro-4-hydroxy-
CBNumber: CB22565572
Molecular Formula: C7H4BrFO2
Formula Weight: 219.01
MOL File: 185345-46-4.mol

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3-broMo-5-fluoro-4-hydroxybenzaldehyde Property

Boiling point:: 238.9±35.0 °C(Predicted)
Density: 1.826±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 5.00±0.23(Predicted)
Appearance: Off-white to light brown Powder

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Safety

HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B686838
Product name: 3-Bromo-5-fluoro-4-hydroxybenzaldehyde
Packaging: 1g
Price: $90
Updated: 2021/12/16

Apolloscientific

Product number: PC905038
Product name: 3-Bromo-5-fluoro-4-hydroxybenzaldehyde
Purity: 95+%
Packaging: 1g
Price: $32
Updated: 2021/12/16

Apolloscientific

Product number: PC905038
Product name: 3-Bromo-5-fluoro-4-hydroxybenzaldehyde
Purity: 95+%
Packaging: 5g
Price: $127
Updated: 2021/12/16

AK Scientific

Product number: Z4328
Product name: 3-Bromo-5-fluoro-4-hydroxybenzaldehyde
Packaging: 5g
Price: $258
Updated: 2021/12/16

AK Scientific

Product number: Z4328
Product name: 3-Bromo-5-fluoro-4-hydroxybenzaldehyde
Packaging: 10g
Price: $462
Updated: 2021/12/16

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3-broMo-5-fluoro-4-hydroxybenzaldehyde Chemical Properties,Usage,Production

Uses

3-Bromo-5-fluoro-4-hydroxybenzaldehyde can be used to prepare derivatives to treat malignant tumor, as well as, CRTH2 receptor inhibitors to treat inflammatory disorders.

Synthesis

405-05-0

185345-46-4

Synthesis of 3-bromo-5-fluoro-4-hydroxybenzaldehyde (26): 3-fluoro-4-hydroxybenzaldehyde (2 g, 14.3 mmol, 1 eq.) was dissolved in acetic acid (60 mL) and bromine (2.7 g, 17.0 mmol, 1.2 eq.) was added slowly to a solution of acetic acid (10 mL). The reaction mixture was stirred at 45°C for 26 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure and saturated saline (50 mL) was added to the residue and extracted with ethyl acetate (3 x 80 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by reversed-phase semi-preparative high-performance liquid chromatography (HPLC) to afford the target product 3-bromo-5-fluoro-4-hydroxybenzaldehyde (26) 1.5 g in 48% yield.

References

[1] Patent: WO2010/102154, 2010, A2. Location in patent: Page/Page column 56
[2] Patent: WO2011/2814, 2011, A2. Location in patent: Page/Page column 48

3-broMo-5-fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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185345-46-4, 3-broMo-5-fluoro-4-hydroxybenzaldehydeRelated Search:

3-broMo-5-fluoro-4-hydroxybenzaldehyde

3-fluoro-4-hydroxy-5-bromobenzaldehyde

Benzaldehyde, 3-bromo-5-fluoro-4-hydroxy-

185345-46-4