2-AMino-3-forMyl-4-chloropyridine
- Product Name
- 2-AMino-3-forMyl-4-chloropyridine
- CAS No.
- 884004-48-2
- Chemical Name
- 2-AMino-3-forMyl-4-chloropyridine
- Synonyms
- 2-amino-4-chloronicotinaldehyde;2-Amino-4-chloro-pyridine-3-carbaldehyde;2-AMino-3-forMyl-4-chloropyridine;3-Pyridinecarboxaldehyde, 2-amino-4-chloro-
- CBNumber
- CB22570590
- Molecular Formula
- C6H5ClN2O
- Formula Weight
- 156.57
- MOL File
- 884004-48-2.mol
2-AMino-3-forMyl-4-chloropyridine Property
- Boiling point:
- 308.4±42.0 °C(Predicted)
- Density
- 1.442±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.89±0.47(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A602878
- Product name
- 2-Amino-4-chloronicotinaldehyde
- Packaging
- 500mg
- Price
- $1020
- Updated
- 2021/12/16
- Product number
- 123027
- Product name
- 2-Amino-4-chloronicotinaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $941
- Updated
- 2021/12/16
- Product number
- 1504AJ
- Product name
- 2-Amino-4-chloronicotinaldehyde
- Packaging
- 100mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 1504AJ
- Product name
- 2-Amino-4-chloronicotinaldehyde
- Packaging
- 250mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 69R0601
- Product name
- 2-Amino-4-chloro-pyridine-3-carbaldehyde
- Purity
- 97%
- Packaging
- 100mg
- Price
- $125
- Updated
- 2021/12/16
2-AMino-3-forMyl-4-chloropyridine Chemical Properties,Usage,Production
Uses
2-Amino-4-chloronicotinaldehyde is a useful synthetic compound.
Synthesis
130721-78-7
68-12-2
884004-48-2
In a round-bottomed flask equipped with a stirrer, thermometer and reflux condenser, 135 mL of anhydrous tetrahydrofuran (THF), 20 g (0.169 mol) of N,N,N',N'-tetramethylethylenediamine, and 15.7 g (0.068 mol) of 2-BOC-amino-4-chloropyridine were added sequentially. The reaction mixture was cooled to -78°C and 68 mL of a 2.5 M hexane solution of n-butyllithium was slowly added dropwise, keeping the reaction temperature constant. After the dropwise addition was completed, stirring was continued at -78°C for 30 min. Subsequently, 15 g (0.2 mol) of N,N-dimethylformamide (DMF) was added, keeping the temperature at -78°C. After the reaction was completed for 1 h, the cooling was stopped, and the reaction mixture was allowed to warm up naturally to room temperature and stirring was continued for 1 h. The reaction was then continued for 1 h. After the reaction was completed, the reaction mixture was allowed to warm up naturally to room temperature. Upon completion of the reaction, 30 mL of methanol and 150 mL of aqueous ammonium chloride were added sequentially under cooling conditions and allowed to stand for 30 minutes. 1000 mL of water and 500 mL of dichloromethane were added to the reaction mixture and the mixture was transferred to a partition funnel to separate the organic layer. The aqueous layer was re-extracted once with 200 mL of dichloromethane. The organic layers were combined, washed with water and dried over anhydrous sodium sulfate. The dichloromethane was removed by distillation under reduced pressure and the residue was dissolved in 200 mL of dichloromethane. Under stirring and cooling conditions, 50 mL of 1,4-dioxane solution in 4 M hydrochloric acid was added to the solution and allowed to stand at room temperature for 5 h. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, 200 mL of dichloromethane was added and the excess acid was neutralized with 2 M sodium hydroxide solution. The organic layer was separated, washed with water and dried over anhydrous sodium sulfate. Finally, the product was purified by column chromatography using dichloromethane as eluent to give 9.6 g (55% yield) of 2-amino-4-chloronicotinaldehyde.
References
[1] Patent: WO2018/92047, 2018, A1. Location in patent: Page/Page column 85
2-AMino-3-forMyl-4-chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMino-3-forMyl-4-chloropyridine manufacturers
- Product
- 2-AMino-3-forMyl-4-chloropyridine 884004-48-2
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12